Evidence map›Paper›PMID 37427535›Full record

ArticleMagnetic resonance in medicine2023

Longitudinal assessment of mitochondrial dysfunction in acute traumatic brain injury using hyperpolarized [1-

Edward P Hackett, Jun Chen, Laura Ingle, Sarah Al Nemri, Surendra Barshikar, Marco da Cunha Pinho, Erik J Plautz, Brenda L Bartnik-Olson, Jae Mo Park

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. HyperpolarizedImaging neuroscience (Cambridge, Mass.) · 2026
    Article
  3. Article
  4. Metabolic Imaging of Hyperpolarized [1-International journal of molecular sciences · 2025
    Article
  5. Traumatic Brain Injury and Coenzyme Q10: An Overview.International journal of molecular sciences · 2025
    Review
  6. Hyperpolarized [1-Brain communications · 2025
    Article
  7. Enhanced Solubility and Polarization ofACS applied materials & interfaces · 2024
    Article
  8. Tracing the path of disruption:CNS neuroscience & therapeutics · 2024
    Review
  9. Investigating the origin of theNMR in biomedicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Edward P HackettAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-7344-6076
Jun ChenAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-5814-1653
Laura IngleDepartment of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Sarah Al NemriAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Surendra BarshikarDepartment of Physical Medicine and Rehabilitation, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Marco da Cunha PinhoDepartment of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Erik J PlautzDepartment of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Brenda L Bartnik-OlsonDepartment of Radiology, Loma Linda University, Loma Linda, California, USA.
Jae Mo ParkAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-7404-6971
Advanced Imaging Research (United States) · USThe University of Texas Southwestern Medical Center · USLoma Linda University · US

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
A Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0M
NIBIB NIH HHS P41 EB015908NIDDK NIH HHS P30 DK127984NIH HHS S10 OD018468NINDS NIH HHS R01 NS107409
6 · The paper itself

Abstract

purpose[

methodsMale Wistar rats were randomly assigned to undergo a controlled-cortical impact (CCI, n = 31) or sham surgery (n = 22). Seventeen of the CCI and 9 of the sham rats longitudinally underwent a

resultsIn addition to elevated lactate, we observed significantly reduced bicarbonate production in the injured site. Unlike the immediate appearance of hyperintensity on T

conclusionThis study demonstrates that aberrant mitochondrial metabolism occurring in acute TBI can be monitored by detecting [

Indexed as

Brain InjuriesBrain Injuries, TraumaticAnimalsBicarbonatesCarbon IsotopesMaleMitochondriaPyruvic AcidRatsRats, WistarBicarbonatesCarbon IsotopesPyruvic Acidhyperpolarizationmetabolic imagingmitochondrial dysfunctionpyruvate dehydrogenasetraumatic brain injury

Identifiers

PMID37427535
PMCPMC10543630
OpenAlexW4383709924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.