Evidence map›Paper›PMID 37427297›Full record

ReviewArrhythmia & electrophysiology review2023

Machine Learning and the Conundrum of Stroke Risk Prediction.

Yaacoub Chahine, Matthew J Magoon, Bahetihazi Maidu, Juan C Del Álamo, Patrick M Boyle, Nazem Akoum

Abstract readReview
In one paragraph

Review in Arrhythmia & electrophysiology review, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaacoub ChahineDivision of Cardiology, University of Washington, Seattle, WA, US.
Matthew J MagoonDepartment of Bioengineering, University of Washington, Seattle, WA, US.
Bahetihazi MaiduDepartment of Mechanical Engineering, University of Washington, Seattle, WA, US.
Juan C Del ÁlamoDepartment of Mechanical Engineering, University of Washington, Seattle, WA, US.
Patrick M BoyleDepartment of Bioengineering, University of Washington, Seattle, WA, US.
Nazem AkoumDivision of Cardiology, University of Washington, Seattle, WA, US.

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
Mechanistic Relationships Between Fibrosis, Fibrillation, and Stroke: Multi-Scale, Multi-Physics SimulationsR01HL158667 · NHLBI · UNIVERSITY OF WASHINGTON · PI Patrick M Boyle · 2022 to 2026
$3.1M
Patient-specific thrombosis risk in atrial fibrillation by 4D CT imaging of atrial kinetics combined with computational fluid dynamicsR01HL160024 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEL ALAMO, JUAN CARLOS, KAHN, ANDREW · 2021 to 2024
$2.7M
NCATS NIH HHS UL1 TR002319NHLBI NIH HHS R01 HL158667NIGMS NIH HHS T32 GM007266
6 · The paper itself

Abstract

Stroke is a leading cause of death worldwide. With escalating healthcare costs, early non-invasive stroke risk stratification is vital. The current paradigm of stroke risk assessment and mitigation is focused on clinical risk factors and comorbidities. Standard algorithms predict risk using regression-based statistical associations, which, while useful and easy to use, have moderate predictive accuracy. This review summarises recent efforts to deploy machine learning (ML) to predict stroke risk and enrich the understanding of the mechanisms underlying stroke. The surveyed body of literature includes studies comparing ML algorithms with conventional statistical models for predicting cardiovascular disease and, in particular, different stroke subtypes. Another avenue of research explored is ML as a means of enriching multiscale computational modelling, which holds great promise for revealing thrombogenesis mechanisms. Overall, ML offers a new approach to stroke risk stratification that accounts for subtle physiologic variants between patients, potentially leading to more reliable and personalised predictions than standard regression-based statistical associations.

Indexed as

atrial fibrillationCardiovascular diseasecomputational fluid dynamicscomputational modellingmultiscale modellingneural networksthromboembolism

Identifiers

PMID37427297
PMCPMC10326666

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.