Evidence map›Paper›PMID 37426945›Full record

ArticleOpen forum infectious diseases2023

Multidrug Resistance of

Jennifer H Ku, Katia J Bruxvoort, S Bianca Salas, Cara D Varley, Joan A Casey, Eva Raphael, Sarah C Robinson, Keeve E Nachman, Bruno J Lewin, Richard Contreras and 4 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Pangenome analysis ofAntimicrobial agents and chemotherapy · 2026
    Article
  4. Therapeutic strategies for multi-resistantJAC-antimicrobial resistance · 2026
    Review
  5. Article
  6. ZoonoticmBio · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. A review of the mechanisms that confer antibiotic resistance in pathotypes ofFrontiers in cellular and infection microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Jennifer H KuDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.ORCID https://orcid.org/0000-0001-9469-5875
Katia J BruxvoortDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
S Bianca SalasDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Cara D VarleyDepartment of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Joan A CaseyDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.ORCID https://orcid.org/0000-0002-9809-4695
Eva RaphaelDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Sarah C RobinsonCenter for Health Systems Research, Sutter Health, Walnut Creek, California, USA.ORCID https://orcid.org/0000-0003-2336-8476
Keeve E NachmanDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Bruno J LewinDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Richard ContrerasDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Rong X WeiDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Magdalena E PomichowskiDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Harpreet S TakharDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Sara Y TartofDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Kaiser Permanente · USJohns Hopkins University · USPortland State University · USSutter Health · USUniversity of California, San Francisco · USUniversity of Washington · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Community-onset urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in women of diverse backgroundsK23AI166030 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eva Raphael · 2022 to 2026
$1.1M
NIAID NIH HHS K23 AI166030NIAID NIH HHS L30 AI154576NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

Background: Urinary tract infections (UTIs) cause significant disease and economic burden. Uncomplicated UTIs (uUTIs) occur in otherwise healthy individuals without underlying structural abnormalities, with uropathogenic Methods: We evaluated UPEC resistance over time by care setting (in-person vs virtual), in adults who received outpatient care for uUTI at Kaiser Permanente Southern California between January 2016 and December 2021. Results: We included 174 185 individuals who had ≥1 UPEC uUTI (233 974 isolates) (92% female, 46% Hispanic, mean age 52 years [standard deviation 20]). Overall, prevalence of UPEC MDR decreased during the study period (13% to 12%) both in virtual and in-person settings ( Conclusions: We observed a slight decrease in both class-specific antimicrobial resistance and MDR of UPEC overall, most commonly involving penicillins and TMP-SMX. Resistance patterns were consistent over time and similar in both in-person and virtual settings. Virtual healthcare may expand access to UTI care.

Indexed as

multidrug antibiotic resistanceurinary tract infectionuropathogenic Escherichia coli

Identifiers

PMID37426945
PMCPMC10326677
OpenAlexW4377861747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.