ArticleFrontiers in pharmacology2023
Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro.
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In one paragraph
Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 13 citations in OpenAlex.
- Computer-Aided Discovery of Drugs Against Chagas Disease.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Application of Data-Centric Supervised Machine Learning to Predict Phenotypic Activity Against Clinically Relevant Stages ofPharmaceutics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors at 16 institutions in 9 countries.
Santiago M RuattaLaboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Denis N Prada GoriLaboratory of Bioactive Compound Research and Development (LIDeB), Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
Martín Fló DíazLaboratory of Immunovirology, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Franca LorenzelliLaboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Karen PerelmuterCell Biology Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Lucas N AlbercaLaboratory of Bioactive Compound Research and Development (LIDeB), Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
Carolina L BelleraLaboratory of Bioactive Compound Research and Development (LIDeB), Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
Andrea MedeirosLaboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Gloria V LópezDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Mariana IngoldVascular Biology and Drug Discovery Lab, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Williams PorcalDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Estefanía DibelloDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Irina IhnatenkoPVZ-Center of Pharmaceutical Engineering, Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Braunschweig, Germany.
Conrad KunickPVZ-Center of Pharmaceutical Engineering, Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Braunschweig, Germany.
Marcelo IncertiDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Martín LuzardoDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Maximiliano ColobbioDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Juan Carlos RamosDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Eduardo MantaDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Lucía MininiDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
María Laura LavaggiLaboratorio de Química Biológica Ambiental, Sede Rivera, Centro Universitario Regional Noreste, Universidad de la República, Montevideo, Uruguay.
Paola HernándezDepartamento de Genética, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
Jonas ŠarlauskasLife Sciences Centre, Department of Xenobiotic Biochemistry, Institute of Biochemistry, Vilnius University, Vilnius, Lithuania.
César Sebastian Huerta GarcíaDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico.
Rafael CastilloDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico.
Alicia Hernández-CamposDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico.
Giovanni RibaudoDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Giuseppe ZagottoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Renzo CarlucciFacultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Química Rosario (IQUIR) UNR, CONICET, Universidad Nacional de Rosario, Rosario, Argentina.
Noelia S MedránFacultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Química Rosario (IQUIR) UNR, CONICET, Universidad Nacional de Rosario, Rosario, Argentina.
Guillermo R LabadieFacultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Química Rosario (IQUIR) UNR, CONICET, Universidad Nacional de Rosario, Rosario, Argentina.
Maitena Martinez-AmezagaFacultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Química Rosario (IQUIR) UNR, CONICET, Universidad Nacional de Rosario, Rosario, Argentina.
Carina M L DelpiccoloFacultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Química Rosario (IQUIR) UNR, CONICET, Universidad Nacional de Rosario, Rosario, Argentina.
Ernesto G MataFacultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Química Rosario (IQUIR) UNR, CONICET, Universidad Nacional de Rosario, Rosario, Argentina.
Laura ScaroneDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Laura PosadaDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Gloria SerraDepartamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Theodora CalogeropoulouInstitute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece.
Kyriakos ProusisInstitute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece.
Anastasia DetsiLaboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Athens, Greece.
Mauricio CabreraLaboratorio de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Paysandú, Uruguay.
Guzmán AlvarezLaboratorio de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Paysandú, Uruguay.
Adrián AicardoDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Verena AraújoDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Cecilia ChavarríaDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Lucija Peterlin MašičFakulteta za farmacijo, Univerza v Ljubljani, Ljubljana, Slovenia.
Melisa E GantnerLaboratory of Bioactive Compound Research and Development (LIDeB), Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
Manuel A LlanosLaboratory of Bioactive Compound Research and Development (LIDeB), Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
Santiago RodríguezLaboratory of Bioactive Compound Research and Development (LIDeB), Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
Luciana GavernetLaboratory of Bioactive Compound Research and Development (LIDeB), Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
Soonju ParkScreening Discovery Platform, Institut Pasteur Korea, Seongnam, Republic of Korea.
Jinyeong HeoScreening Discovery Platform, Institut Pasteur Korea, Seongnam, Republic of Korea.
Honggun LeeScreening Discovery Platform, Institut Pasteur Korea, Seongnam, Republic of Korea.
Kyu-Ho Paul ParkScreening Discovery Platform, Institut Pasteur Korea, Seongnam, Republic of Korea.
Mariela Bollati-FogolínCell Biology Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Otto PritschLaboratory of Immunovirology, Institut Pasteur de Montevideo, Montevideo, Uruguay.
David ShumScreening Discovery Platform, Institut Pasteur Korea, Seongnam, Republic of Korea.
Alan TaleviLaboratory of Bioactive Compound Research and Development (LIDeB), Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
Marcelo A CominiLaboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Universidad de la República · UYConsejo Nacional de Investigaciones Científicas y Técnicas · ARInstitut Pasteur de Montevideo · UYInstitut Pasteur Korea · KRUniversidad Nacional de La Plata · ARUniversidad Nacional Autónoma de México · MXNational Hellenic Research Foundation · GRTechnische Universität Braunschweig · DEInstituto de Investigaciones Biológicas Clemente Estable · UYNational Technical University of Athens · GRNational University of Rosario · ARNational University of the Littoral · ARUniversity of Brescia · ITUniversity of Ljubljana · SIUniversity of Padua · ITVilnius University · LT
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
artificial intelligencecoronavirusCOVID-19drug discoveryin silico screeningproteaserubbish in rubbish outtarget-based
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.