Evidence map›Paper›PMID 37426757›Full record

ArticleCell reports methods2023

Directed stepwise tracing of polysynaptic neuronal circuits with replication-deficient pseudorabies virus.

Wenqin Du, Elizabeth Li, Jun Guo, Rachel Arano, Yerim Kim, Yuh-Tarng Chen, Alyssa Thompson, So Jung Oh, Aspen Samuel, Ying Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenqin DuDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Elizabeth LiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jun GuoDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Rachel AranoDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yerim KimDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yuh-Tarng ChenDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Alyssa ThompsonDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
So Jung OhDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Aspen SamuelDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ying LiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Hassana K OyiboFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Wei XuDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Funding

Elucidating the Wiring and Rewiring of Poly-synaptic Memory Circuits by Directed Stepwise Trans-neuronal TracingR01NS104828 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI XU, WEI · 2018 to 2022
$2.0M
NINDS NIH HHS R01 NS104828
6 · The paper itself

Abstract

Brain functions are accomplished by polysynaptic circuits formed by neurons wired together through multiple orders of synaptic connections. Polysynaptic connectivity has been difficult to examine due to a lack of methods of continuously tracing the pathways in a controlled manner. Here, we demonstrate directed, stepwise retrograde polysynaptic tracing by inducible reconstitution of replication-deficient

Indexed as

Herpesvirus 1, SuidPseudorabiesAnimalsBrainNeuronsVirus Replicationanterogradehippocampuspolysynaptic circuitpseudorabies virusretrogradestriatumtrans-complementationtrans-synaptic tracing

Identifiers

PMID37426757
PMCPMC10326449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.