Evidence map›Paper›PMID 37426753›Full record

ArticleCell reports methods2023

Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods.

Fabian Otte, Yuepeng Zhang, Julian Spagnuolo, Alexander Thielen, Martin Däumer, Carsten Wiethe, Marcel Stoeckle, Katharina Kusejko, Florian Klein, Karin J Metzner and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Fabian OtteMolecular Virology, Department Biomedicine, University of Basel, 4009 Basel, Switzerland.
Yuepeng ZhangMolecular Virology, Department Biomedicine, University of Basel, 4009 Basel, Switzerland.
Julian SpagnuoloExperimental Immunology, Department Biomedicine, University of Basel, 4056 Basel, Switzerland.
Alexander ThielenSeq-IT GmbH & Co.KG, 67655 Kaiserslautern, Germany.
Martin DäumerSeq-IT GmbH & Co.KG, 67655 Kaiserslautern, Germany.
Carsten WietheBiolegend GmbH, 56070 Koblenz, Germany.
Marcel StoeckleInfectiology, University Hospital Basel, 4031 Basel, Switzerland.
Katharina KusejkoDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, and Institute of Medical Virology, University of Zurich, 8091 Zurich, Switzerland.
Florian KleinLaboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Karin J MetznerDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, and Institute of Medical Virology, University of Zurich, 8091 Zurich, Switzerland.
Thomas KlimkaitMolecular Virology, Department Biomedicine, University of Basel, 4009 Basel, Switzerland.
Swiss HIV Cohort Study
University of Basel · CHViiV Healthcare (Spain) · ESUniversity of Zurich · CHUniversity Hospital of Basel · CHUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While combination therapy completely suppresses HIV-1 replication in blood, functional virus persists in CD4

Indexed as

HIV-1HIV InfectionsHIV SeropositivityCD4-Positive T-LymphocytesHumansT-Lymphocyte SubsetsbNAbscell homingDBscanGag and Envelope co-detection assayGERDAHIV-1 quantificationHIV-1 reservoirHIV-1 reservoirsHIV-1 viral outgrowthHIV-1 virus dynamicstSNE

Identifiers

PMID37426753
PMCPMC10326345
OpenAlexW4377861642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.