Evidence map›Paper›PMID 37426673›Full record

ArticleFrontiers in immunology2023

Brain transcriptomics reveal the activation of neuroinflammation pathways during acute

Yuejin Liang, Aditi, Florence Onyoni, Hui Wang, Casey Gonzales, Piyanate Sunyakumthorn, Ping Wu, Parimal Samir, Lynn Soong

Abstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Movement Disorders in Scrub Typhus: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuejin LiangDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
AditiDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
Florence OnyoniDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
Hui WangDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Casey GonzalesDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Piyanate SunyakumthornDepartment of Veterinary Medicine, United States Army Medical Directorate, Armed Forces Research Institute of Medical Sciences (United States MD-AFRIMS), Bangkok, Thailand.
Ping WuDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX, United States.
Parimal SamirDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
Lynn SoongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.

Funding

Biodefense Training ProgramT32AI060549 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ASHOK K CHOPRA, Janice J Endsley · 2004 to 2026
$3.0M
Pathogenic Mechanisms of Vascular Dysfunction in Scrub TyphusR01AI132674 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Yuejin Liang, LYNN SOONG · 2018 to 2026
$3.0M
PREPing for SUCCESSR25GM134990 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI VARGAS, GRACIE · 2020 to 2024
$1.2M
Neutrophil-Mediated Bacterial Dissemination and Host Immunopathogenesis in a Murine Scrub Typhus ModelR21AI153586 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LIANG, YUEJIN · 2020 to 2021
$435k
Mincle and STING Activation in Proinflammatory Responses to Orientia InfectionR21AI156536 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SOONG, LYNN · 2021 to 2022
$435k
NIAID NIH HHS R01 AI132674NIAID NIH HHS R21 AI153586NIAID NIH HHS R21 AI156536NIAID NIH HHS T32 AI060549NIGMS NIH HHS R25 GM134990
6 · The paper itself

Abstract

Scrub typhus, an acute febrile illness caused by

Indexed as

Orientia tsutsugamushiScrub TyphusAnimalsBrainMiceNeuroinflammatory DiseasesTranscriptomeBBB disruptionIFN responseinnate immune activationmicroglial activationneuroinflammationRNA-Seq - RNA sequencingscrub typhus

Identifiers

PMID37426673
PMCPMC10326051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.