Evidence map›Paper›PMID 37426429›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2023

Helical TomoTherapy Total Lymphoid Irradiation and Hematopoietic Cell Transplantation for Kidney Transplant Tolerance in Rhesus Macaques.

Dixon B Kaufman, Lisa J Forrest, John Fechner, Jennifer Post, Jennifer Coonen, Lynn D Haynes, W John Haynes, Neil Christensen, Weixiong Zhong, Christopher J Little and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Dixon B KaufmanDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
Lisa J ForrestSchool of Veternary Medicine, University of Wisconsin, Madison, WI, United States.
John FechnerDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
Jennifer PostDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
Jennifer CoonenWisconsin National Primate Research Center, University of Wisconsin, Madison, WI, United States.
Lynn D HaynesDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
W John HaynesDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
Neil ChristensenSchool of Veternary Medicine, University of Wisconsin, Madison, WI, United States.
Weixiong ZhongDepartment of Pathology, University of Wisconsin, Madison, WI, United States.
Christopher J LittleDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
Anthony D'AlessandroDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
Luis FernandezDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
Kevin BrunnerWisconsin National Primate Research Center, University of Wisconsin, Madison, WI, United States.
Kent JensenDepartment of Medicine, Stanford University, Palo Alto, CA, United States.
William J BurlinghamDepartment of Surgery, University of Wisconsin, Madison, WI, United States.
Peiman HemattiDepartment of Medicine, University of Wisconsin, Madison, WI, United States.
Samuel StroberDepartment of Medicine, Stanford University, Palo Alto, CA, United States.
University of Wisconsin–Madison · USStanford University · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
NIH HHS P51 OD011106
6 · The paper itself

Abstract

Development of a post-transplant kidney transplant tolerance induction protocol involving a novel total lymphoid irradiation (TLI) conditioning method in a rhesus macaque model is described. We examined the feasibility of acheiving tolerance to MHC 1-haplotype matched kidney transplants by establishing a mixed chimeric state with infusion of donor hematopoietic cells (HC) using TomoTherapy TLI. The chimeric state was hypothesized to permit the elimination of all immunosuppressive (IS) medications while preserving allograft function long-term without development of graft-versus-host-disease (GVHD) or rejection. An experimental group of 11 renal transplant recipients received the tolerance induction protocol and outcomes were compared to a control group (

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationKidney TransplantationRadiotherapy, Intensity-ModulatedAnimalsImmune ToleranceKidneyLymphatic IrradiationMacaca mulattaTransplantation ChimeraTransplantation ConditioningTransplantation Tolerancechimerismhematopoietic cellskidney transplantationtolerance inductionTomoTherapy

Identifiers

PMID37426429
PMCPMC10324513
OpenAlexW4381855398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.