Evidence map›Paper›PMID 37426420›Full record

ArticleFrontiers in molecular biosciences2023

Sequence- and structure-specific RNA oligonucleotide binding attenuates heterogeneous nuclear ribonucleoprotein A1 dysfunction.

Joseph P Clarke, Patricia A Thibault, Sakina Fatima, Hannah E Salapa, Subha Kalyaanamoorthy, Aravindhan Ganesan, Michael C Levin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joseph P ClarkeDepartment of Health Sciences, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Patricia A ThibaultDepartment of Medicine, Neurology Division, University of Saskatchewan, Saskatoon, SK, Canada.
Sakina FatimaArGan's Lab, School of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, ON, Canada.
Hannah E SalapaDepartment of Medicine, Neurology Division, University of Saskatchewan, Saskatoon, SK, Canada.
Subha KalyaanamoorthyDepartment of Chemistry, Faculty of Science, University of Waterloo, Waterloo, ON, Canada.
Aravindhan GanesanArGan's Lab, School of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, ON, Canada.
Michael C LevinDepartment of Health Sciences, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
University of Saskatchewan · CAUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RNA binding protein heterogeneous nuclear ribonucleoprotein A1 (A1) regulates RNA metabolism, which is crucial to maintaining cellular homeostasis. A1 dysfunction mechanistically contributes to reduced cell viability and loss, but molecular mechanisms of how A1 dysfunction affects cell viability and loss, and methodologies to attenuate its dysfunction, are lacking. Utilizing

Indexed as

hnRNPA1optogeneticsRNA oligonucleotideRNA-protein interactionstress granules

Identifiers

PMID37426420
PMCPMC10325567
OpenAlexW4381930752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.