Evidence map›Paper›PMID 37426322›Full record

ArticleWorld journal of gastroenterology2023

Transcriptome sequencing and experiments reveal the effect of formyl peptide receptor 2 on liver homeostasis.

Hui Liu, Ze-Yu Sun, Hua Jiang, Xu-Dong Li, Yong-Qiang Jiang, Peng Liu, Wen-Hua Huang, Qing-Yu Lv, Xiang-Lilan Zhang, Rong-Kuan Li

Open access · hybridAbstract read
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In one paragraph

Article in World journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hui LiuDepartment of Gastroenterology, Second Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China.
Ze-Yu SunState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Hua JiangState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Xu-Dong LiMicrobiology Teaching and Research Office, Anhui Medical University, Hefei 230032, Anhui Province, China.
Yong-Qiang JiangState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Peng LiuState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Wen-Hua HuangState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Qing-Yu LvState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Xiang-Lilan ZhangState Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Rong-Kuan LiDepartment of Infectious Diseases, Second Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China. dalianlrk1@163.com.
Institute of Microbiology · CNAcademy of Military Medical Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFormyl peptide receptor 2 (Fpr2) is an important receptor in host resistance to bacterial infections. In previous studies, we found that the liver of Fpr2

aimTo investigate the role of Fpr2 in liver homeostasis and host resistance to bacterial infections.

methodsTranscriptome sequencing was performed on the livers of Fpr2

resultsCompared with the WT group, 445 DEGs, including 325 upregulated genes and 120 downregulated genes, were identified in the liver of Fpr2

conclusionFpr2 participates in the regulation of cell cycle and cell proliferation, and affects the expression of IL-10 and CXCL-1, thus playing an important protective role in maintaining liver homeostasis.

Indexed as

Receptors, Formyl PeptideTranscriptomeAnimalsCell CycleCell Cycle ProteinsLiverMiceCell Cycle Proteinsformyl peptide receptor 2, mouseReceptors, Formyl PeptideCdk1Cell cycleCell proliferationDifferentially expressed genesFormyl peptide receptor 2RNA-sequencing

Identifiers

PMID37426322
PMCPMC10324526
OpenAlexW4382279953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.