Evidence map›Paper›PMID 37426019›Full record

ArticleFrontiers in microbiology2023

Evaluation of

Luis G V Fernandes, Aline F Teixeira, Ana L T O Nascimento

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Advances in the development of a vaccine for the prevention of human leptospirosis: a review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Comparative genomics ofFrontiers in microbiology · 2024
    Article
  10. LipL41 and LigA/LigB Gene Silencing on a LipL32 KnockoutPathogens (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Luis G V FernandesLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, SP, Brazil.
Aline F TeixeiraLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, SP, Brazil.
Ana L T O NascimentoLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, SP, Brazil.
Instituto Butantan · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Leptospirosis is a worldwide zoonosis caused by pathogenic and virulent species of the genus Methods: In this work, we tailored plasmids for silencing the major proteins of Results: OmpL1 silencing resulted in a lethal phenotype, in both Discussion: CRISPRi is now a well-established, attractive genetic tool that can be applied for exploring leptospiral virulence factors, leading to the rational for designing more effective subunit or even chimeric recombinant vaccines.

Indexed as

CRISPR interferencehost-pathogen interactionsknockdown mutantsLipL21LipL32LipL41OmpL1virulence

Identifiers

PMID37426019
PMCPMC10326724
OpenAlexW4381996532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.