Evidence map›Paper›PMID 37425960›Full record

ArticlebioRxiv : the preprint server for biology2023

The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix.

Joseph G O'Brien, Alexander B Willis, Ashlee M Long, Jason Kwon, GaHyun Lee, Frank Li, Patrick G T Page, Andy H Vo, Michele Hadhazy, Rachelle H Crosbie and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Joseph G O'BrienCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Alexander B WillisCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Ashlee M LongCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jason KwonCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
GaHyun LeeCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Frank LiCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Patrick G T PageCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Andy H VoCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Michele HadhazyCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Rachelle H CrosbieDepartment of Integrative Biology and Physiology, UCLA, Los Angeles, CA; Department of Neurology David Geffen School of Medicine, UCLA, Los Angeles, CA.
Alexis R DemonbreunCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Elizabeth M McNallyCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Northwestern University · USUniversity of California, Los Angeles · US

Funding

Training and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1M
SARCOGLYCAN IN MYOPATHY AND MUSCLE MEMBRANE STABILITYR01HL061322 · NHLBI · UNIVERSITY OF CHICAGO · PI MCNALLY, ELIZABETH M · 1999 to 2022
$7.5M
Myoferlin in Muscle Membrane Fusion and RepairR01NS047726 · NINDS · UNIVERSITY OF CHICAGO · PI ALEXIS R. DEMONBREUN, Elizabeth M McNally · 2003 to 2026
$7.2M
Understanding and Improving Therapies for the Muscular Dystrophies through Noninvasive BiomarkersP50AR052646 · NIAMS · UNIVERSITY OF FLORIDA · PI WALTER, GLENN · 2021 to 2024
$6.2M
NHLBI NIH HHS R01 HL061322NIAMS NIH HHS P50 AR052646NIAMS NIH HHS U54 AR052646NINDS NIH HHS R01 NS047726
6 · The paper itself

Abstract

Genetic background shifts the severity of muscular dystrophy. In mice, the DBA/2J strain confers a more severe muscular dystrophy phenotype, whereas the Murphy's Roth Large (MRL) strain has "super-healing" properties that reduce fibrosis. A comparative analysis of the

Indexed as

extracellular matrixLGMDLimb girdle muscular dystrophyMRLmusclesuper-healingTGF-β

Identifiers

PMID37425960
PMCPMC10327155
OpenAlexW4382678676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.