Evidence map›Paper›PMID 37425954›Full record

ArticlebioRxiv : the preprint server for biology2023

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease

Nadja Straumann, Benjamin F Combes, Xose Luis Dean Ben, Rebecca Sternke-Hoffmann, Juan A Gerez, Ines Dias, Zhenyue Chen, Benjamin Watts, Iman Rostami, Kuangyu Shi and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Nadja StraumannInstitute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Benjamin F CombesInstitute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Xose Luis Dean BenInstitute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland.
Rebecca Sternke-HoffmannDepartment of Biology and Chemistry, Paul Scherrer Institute, Villigen, Switzerland.
Juan A GerezETH Zurich, Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, Zurich, Switzerland.
Ines DiasNeurology Department, University Hospital Zurich, Zurich, Switzerland.
Zhenyue ChenInstitute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland.
Benjamin WattsPhoton Science Division, Paul Scherrer Institute, Villigen, Switzerland.
Iman RostamiMicroscopic Anatomy and Structural Biology, University of Bern, Bern, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Christian R BaumannNeurology Department, University Hospital Zurich, Zurich, Switzerland.
Jinghui LuoDepartment of Biology and Chemistry, Paul Scherrer Institute, Villigen, Switzerland.
Daniela NoainNeurology Department, University Hospital Zurich, Zurich, Switzerland.
Roger M NitschInstitute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Nobuyuki OkamuraDivision of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Daniel RazanskyInstitute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland.
Ruiqing NiInstitute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
University of Zurich · CHPaul Scherrer Institute · CHUniversity Hospital of Zurich · CHUniversity of Bern · CHETH Zurich · CHTohoku Medical and Pharmaceutical University · JP

Funding

High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin SupplementRF1NS126102 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CAMPBELL, ROBERT E., RAZANSKY, DANIEL · 2022 to 2024
$3.1M
NINDS NIH HHS RF1 NS126102
6 · The paper itself

Abstract

Background: Abnormal alpha-synuclein and iron accumulation in the brain play an important role in Parkinson's disease (PD). Herein, we aim at visualizing alpha-synuclein inclusions and iron deposition in the brains of M83 (A53T) mouse models of PD Methods: Fluorescently labelled pyrimidoindole-derivative THK-565 was characterized by using recombinant fibrils and brains from 10-11 months old M83 mice, which subsequently underwent Results: THK-565 showed increased fluorescence upon binding to recombinant alpha-synuclein fibrils and alpha-synuclein inclusions in post-mortem brain slices from patients with Parkinson's disease and M83 mice. Conclusion: We demonstrated

Indexed as

alpha-synucleinfluorescence imagingironmagnetic resonance imagingoptoacoustic imagingParkinson’s diseasesusceptibility weighted imaging

Identifiers

PMID37425954
PMCPMC10327184
OpenAlexW4382652160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.