Evidence map›Paper›PMID 37425949›Full record

ArticlebioRxiv : the preprint server for biology2023

Di-berberine conjugates as chemical probes of

Logan G Kavanaugh, Andrew R Mahoney, Debayan Dey, William M Wuest, Graeme L Conn

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Logan G KavanaughDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA.
Andrew R MahoneyDepartment of Chemistry, Emory University, Atlanta, GA.
Debayan DeyDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA.
William M WuestDepartment of Chemistry, Emory University, Atlanta, GA.
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA.
Emory University · US

Funding

Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8M
Molecular basis for substrate discrimination by transporter protein MexY of the MexXY-OprM efflux pump in Pseudomonas aeruginosaF31GM143891 · NIGMS · EMORY UNIVERSITY · PI KAVANAUGH, LOGAN GLENN · 2021 to 2024
$165k
NIGMS NIH HHS F31 GM143891NIGMS NIH HHS R35 GM119426
6 · The paper itself

Abstract

The Resistance-Nodulation-Division (RND) efflux pump superfamily is pervasive among Gram-negative pathogens and contributes extensively to clinical antibiotic resistance. The opportunistic pathogen

Indexed as

antibioticberberineeffluxefflux pump inhibitorMexXY-OprMPseudomonasResistance-Nodulation-Division (RND)

Identifiers

PMID37425949
PMCPMC10327050
OpenAlexW4360942848

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.