Evidence map›Paper›PMID 37425937›Full record

ArticlebioRxiv : the preprint server for biology2023

Neuronal wiring diagram of an adult brain.

Sven Dorkenwald, Arie Matsliah, Amy R Sterling, Philipp Schlegel, Szi-Chieh Yu, Claire E McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin and 37 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 165 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

47 authors at 7 institutions in 3 countries.

Sven DorkenwaldPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Arie MatsliahPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Amy R SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Philipp SchlegelNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Claire E McKellarPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Albert LinPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Marta CostaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Katharina EichlerDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Yijie YinDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Will SilversmithPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Casey Schneider-MizellAllen Institute for Brain Science, Seattle, USA.
Chris S JordanPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Derrick BrittainAllen Institute for Brain Science, Seattle, USA.
Akhilesh HalageriPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Kai KuehnerPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Oluwaseun OgedengbePrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Ryan MoreyPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Jay GagerPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Krzysztof KrukEyewire, Boston, USA.
Eric PerlmanYikes LLC, Baltimore, USA.
Runzhe YangPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
David DeutschPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Doug BlandPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Marissa SorekPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Ran LuPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Thomas MacrinaPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Kisuk LeePrinceton Neuroscience Institute, Princeton University, Princeton, USA.
J Alexander BaePrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Shang MuPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Barak NehoranPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Eric MitchellPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Sergiy PopovychPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Jingpeng WuPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Zhen JiaPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Manuel CastroPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Nico KemnitzPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Dodam IhPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Alexander Shakeel BatesNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Nils EcksteinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, USA.
Jan FunkeJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, USA.
Forrest CollmanAllen Institute for Brain Science, Seattle, USA.
Davi D BockDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, USA.
Gregory S X E JefferisNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
H Sebastian SeungPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
Mala MurthyPrinceton Neuroscience Institute, Princeton University, Princeton, USA.
FlyWire Consortium
Princeton University · USAllen Institute for Brain Science · USUniversity of Cambridge · GBHoward Hughes Medical Institute · USMRC Laboratory of Molecular Biology · GBHarvard University · USUniversity of Vermont · US

Funding

Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Uncovering the Neural Mechanisms that Flexibly Link Sensory Processing to BehaviorR35NS111580 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2019 to 2026
$5.0M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
Accelerating connectomic proofreading for larger brains and multiple individualsRF1MH129268 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA · 2022 to 2022
$2.1M
Automating whole brain connectomics: development, validation, and application of an open toolkitRF1MH120679 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOCK, DAVI · 2019 to 2019
$1.9M
High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequenceRF1NS121911 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SEEDS, ANDREW MICHAEL · 2021 to 2021
$1.4M
High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequenceR01NS121911 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SEEDS, ANDREW MICHAEL · 2024 to 2025
$893k
NIMH NIH HHS RF1 MH117815NIMH NIH HHS RF1 MH120679NIMH NIH HHS RF1 MH129268NINDS NIH HHS R01 NS121911NINDS NIH HHS R35 NS111580NINDS NIH HHS RF1 NS121911NINDS NIH HHS U24 NS126935Wellcome Trust
6 · The paper itself

Abstract

Connections between neurons can be mapped by acquiring and analyzing electron microscopic (EM) brain images. In recent years, this approach has been applied to chunks of brains to reconstruct local connectivity maps that are highly informative, yet inadequate for understanding brain function more globally. Here, we present the first neuronal wiring diagram of a whole adult brain, containing 5×10

Identifiers

PMID37425937
PMCPMC10327113
OpenAlexW4382684379

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.