Evidence map›Paper›PMID 37425930›Full record

ArticlebioRxiv : the preprint server for biology2023

Inserting a Neuropixels probe into awake monkey cortex: two probes, two methods.

Tomoyuki Namima, Erin Kempkes, Bob Smith, Anitha Pasupathy

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Tomoyuki NamimaDepartment of Biological Structure and Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA.
Erin KempkesDepartment of Biological Structure and Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA.
Bob SmithWashington National Primate Research Center Instrumentation Services, University of Washington, Seattle, WA 98195, USA.
Anitha PasupathyDepartment of Biological Structure and Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA.
University of Washington · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5M
The role of area V4 in the perception and recognition of visual objectsR01EY018839 · NEI · UNIVERSITY OF WASHINGTON · PI Anitha Pasupathy · 2009 to 2026
$9.0M
Spatiotemporal representation in ventral visual pathwayR01EY029601 · NEI · UNIVERSITY OF WASHINGTON · PI PASUPATHY, ANITHA · 2021 to 2025
$2.3M
NEI NIH HHS P30 EY001730NEI NIH HHS R01 EY018839NEI NIH HHS R01 EY029601NIH HHS P51 OD010425
6 · The paper itself

Abstract

Neuropixels probes have revolutionized neurophysiological studies in the rodent, but inserting these probes through the much thicker primate dura remains a challenge. Here we describe two methods we have developed for the insertion of two types of Neuropixels probes acutely into the awake monkey cortex. For the fine rodent probe, which is unable to pierce native primate dura, we developed a dural-eyelet method to insert the probe repeatedly without breakage. For the thicker NHP probe, we developed an artificial dura system to insert the probe. We have now conducted successful experiments in 3 animals across 7 recording chambers with the procedures described here and have achieved stable recordings over several months in each case. Here we describe our hardware, surgical preparation, methods for insertion and methods for removal of broken probe parts. We hope that our methods are of value to primate physiologists everywhere.

Indexed as

chronic recording chamberhigh-density silicon probemulti-contact linear probesNonhuman primate neurophysiology

Identifiers

PMID37425930
PMCPMC10326968
OpenAlexW4382516668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.