Evidence map›Paper›PMID 37425885›Full record

ArticlebioRxiv : the preprint server for biology2023

Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals.

Benjamin T Jones, Jaeil Han, He Zhang, Robert E Hammer, Bret M Evers, Dinesh Rakheja, Asha Acharya, Joshua T Mendell

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Benjamin T JonesDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jaeil HanDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
He ZhangQuantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Robert E HammerDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Bret M EversDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Dinesh RakhejaDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Asha AcharyaDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Joshua T MendellDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · US

Funding

The role of long noncoding RNA CRNDE in normal physiology and cancerR01CA282036 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Joshua T Mendell · 2023 to 2026
$1.9M
NCI NIH HHS R01 CA282036
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway in which miRNAs that bind to specialized targets with extensive complementarity are rapidly decayed, has emerged as a potent mechanism of controlling miRNA levels. Nevertheless, the biological role and scope of miRNA regulation by TDMD in mammals remains poorly understood. To address these questions, we generated mice with constitutive or conditional deletion of

Identifiers

PMID37425885
PMCPMC10327180
OpenAlexW4382286160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.