ArticlebioRxiv : the preprint server for biology2023
Zona incerta dopamine neurons encode motivational vigor in food seeking.
Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Energy deprivation triggers food seeking to ensure homeostatic consumption, but the neural coding of motivational vigor in food seeking during physical hunger remains unknown. Here, we report that ablation of dopamine (DA) neurons in zona incerta (ZI) but not ventral tegmental area potently impaired food seeking after fasting. ZI DA neurons were quickly activated for food approach but inhibited during food consumption. Chemogenetic manipulation of ZI DA neurons bidirectionally regulated feeding motivation to control meal frequency but not meal size for food intake. In addition, activation of ZI DA neurons and their projections to paraventricular thalamus transited positive-valence signals to promote acquisition and expression of contextual food memory. Together, these findings reveal that ZI DA neurons encode motivational vigor in food seeking for homeostatic eating. One Sentence Summary: Activation of ZI DA neurons vigorously drives and maintains food-seeking behaviors to ensure food consumption triggered by energy deprivation through inhibitory DA
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