Evidence map›Paper›PMID 37425814›Full record

ArticlebioRxiv : the preprint server for biology2023

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.

Karen A Scott, Yalun Tan, Dominique N Johnson, Khalid Elsaafien, Caitlin Baumer-Harrison, Sophia A Eikenberry, Jessica M Sa, Guillaume de Lartigue, Annette D de Kloet, Eric G Krause

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Karen A ScottDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32611, USA.
Yalun TanDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32611, USA.
Dominique N JohnsonDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32611, USA.
Khalid ElsaafienDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32611, USA.
Caitlin Baumer-HarrisonDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
Sophia A EikenberryDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
Jessica M SaDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
Guillaume de LartigueMonell Chemical Senses Center, Philadelphia, PA 19104, USA.
Annette D de KloetDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
Eric G KrauseDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32611, USA.
University of Florida Health · USMonell Chemical Senses Center · US

Funding

Interrogating stress-relieving neural circuits to alleviate cardiovascular diseaseR35HL150750 · NHLBI · UNIVERSITY OF FLORIDA · PI Eric Gerald Krause · 2020 to 2026
$5.9M
Leveraging vagal oxytocin receptors to understand cardiometabolic interoceptionR56AT012142 · NCCIH · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE, DE LARTIGUE, GUILLAUME FH · 2022 to 2022
$588k
NCCIH NIH HHS R56 AT012142NHLBI NIH HHS R35 HL150750
6 · The paper itself

Abstract

Interoception broadly refers to awareness of one's internal milieu. Vagal sensory afferents monitor the internal milieu and maintain homeostasis by engaging brain circuits that alter physiology and behavior. While the importance of the body-to-brain communication that underlies interoception is implicit, the vagal afferents and corresponding brain circuits that shape perception of the viscera are largely unknown. Here, we use mice to parse neural circuits subserving interoception of the heart and gut. We determine vagal sensory afferents expressing the oxytocin receptor, hereafter referred to as NDG

Identifiers

PMID37425814
PMCPMC10327188
OpenAlexW4382792783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.