Evidence map›Paper›PMID 37425805›Full record

ArticlebioRxiv : the preprint server for biology2023

Synapsin E-domain is essential for α-synuclein function.

Alexandra Stavsky, Leonardo A Parra-Rivas, Shani Tal, Jen Riba, Kayalvizhi Madhivanan, Subhojit Roy, Daniel Gitler

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alexandra StavskyDepartment of Physiology and Cell Biology, Faculty of Health Sciences and School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID 0000-0002-8209-3524
Leonardo A Parra-RivasDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.ORCID 0000-0002-6707-1255
Shani TalDepartment of Physiology and Cell Biology, Faculty of Health Sciences and School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Jen RibaDepartment of Physiology and Cell Biology, Faculty of Health Sciences and School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Kayalvizhi MadhivananDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.ORCID 0000-0002-4241-2922
Subhojit RoyDepartment of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.ORCID 0000-0002-1571-2735
Daniel GitlerDepartment of Physiology and Cell Biology, Faculty of Health Sciences and School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID 0000-0001-9544-3610
Ben-Gurion University of the Negev · ILUniversity of California San Diego · USArrowhead Pharmaceuticals (United States) · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Pathophysiologic roles of alpha-synuclein at the synapseR01NS111978 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROY, SUBHOJIT · 2019 to 2023
$2.4M
NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS111978
6 · The paper itself

Abstract

The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of α-synuclein (α-syn). Synapsin E-domain allows α-syn functionality, binds to α-syn, and is necessary and sufficient for enabling effects of α-syn at the synapse. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters.

Indexed as

pHluorinsynapsessynapsinvesicle poolsα-synuclein

Identifiers

PMID37425805
PMCPMC10327093
OpenAlexW4382049649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.