Evidence map›Paper›PMID 37425793›Full record

ArticlebioRxiv : the preprint server for biology2023

Patterning and folding of intestinal villi by active mesenchymal dewetting.

Tyler R Huycke, Hikaru Miyazaki, Teemu J Häkkinen, Vasudha Srivastava, Emilie Barruet, Christopher S McGinnis, Ali Kalantari, Jake Cornwall-Scoones, Dedeepya Vaka, Qin Zhu and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Tyler R HuyckeDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Hikaru MiyazakiDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Teemu J HäkkinenDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Vasudha SrivastavaDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Emilie BarruetDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Christopher S McGinnisDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Ali KalantariDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Jake Cornwall-ScoonesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Dedeepya VakaDepartment of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, USA.
Qin ZhuDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Hyunil JoDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
William F DeGradoDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Matt ThomsonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Krishna GarikipatiDepartments of Mechanical Engineering, and Mathematics, University of Michigan, Ann Arbor, USA.
Dario BoffelliDepartment of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, USA.
Ophir D KleinProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.
Zev J GartnerDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USCedars-Sinai Medical Center · USCalifornia Institute of Technology · USUniversity of Michigan · US

Funding

Harnessing natural stem cell-based strategies for mammalian dental renewalR35DE026602 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2016 to 2023
$8.0M
The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironmentU01DK103147 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2014 to 2023
$5.4M
The physical and molecular mechanisms of intestinal villus morphogenesis and repairR01DK126376 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Zev Jordan Gartner · 2020 to 2026
$4.2M
Understanding breast cancer progression as a defect in the mechanics of tissue self-organizationU01CA244109 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARTNER, ZEV JORDAN, GOGA, ANDREI · 2020 to 2024
$3.0M
MULTIseq: multiplexing massively parallel single cell transcriptional analysis across time, space, and conditionsR01GM135462 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARTNER, ZEV JORDAN · 2019 to 2022
$1.3M
Mechanochemical mechanisms of intestinal villus development and regenerationF32DK128949 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUYCKE, TYLER · 2021 to 2023
$205k
NCI NIH HHS U01 CA244109NIDCR NIH HHS R35 DE026602NIDDK NIH HHS F32 DK128949NIDDK NIH HHS R01 DK126376NIDDK NIH HHS U01 DK103147NIGMS NIH HHS R01 GM135462
6 · The paper itself

Abstract

Tissue folding generates structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, the numerous finger-like protrusions that are essential for nutrient absorption. However, the molecular and mechanical mechanisms driving the initiation and morphogenesis of villi remain a matter of debate. Here, we identify an active mechanical mechanism that simultaneously patterns and folds intestinal villi. We find that PDGFRA+ subepithelial mesenchymal cells generate myosin II-dependent forces sufficient to produce patterned curvature in neighboring tissue interfaces. At the cell-level, this occurs through a process dependent upon matrix metalloproteinase-mediated tissue fluidization and altered cell-ECM adhesion. By combining computational models with

Identifiers

PMID37425793
PMCPMC10326967
OpenAlexW4382284701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.