Evidence map›Paper›PMID 37425790›Full record

ArticlebioRxiv : the preprint server for biology2023

Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers.

Hannah A Pizzato, Paula Alonso-Guallart, James Woods, Bjarki Johannesson, Jon P Connelly, Todd A Fehniger, John P Atkinson, Shondra M Pruett-Miller, Frederick J Monsma, Deepta Bhattacharya

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hannah A PizzatoDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA.
Paula Alonso-GuallartThe New York Stem Cell Foundation Research Institute, New York, NY, USA.
James WoodsThe New York Stem Cell Foundation Research Institute, New York, NY, USA.
Bjarki JohannessonThe New York Stem Cell Foundation Research Institute, New York, NY, USA.
Jon P ConnellyDepartment of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Todd A FehnigerDivision of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
John P AtkinsonDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Shondra M Pruett-MillerDepartment of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Frederick J MonsmaThe New York Stem Cell Foundation Research Institute, New York, NY, USA.
Deepta BhattacharyaDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA.
New York Stem Cell Foundation · USSt. Jude Children's Research Hospital · USUniversity of Arizona · USWashington University in St. Louis · US

Funding

Targeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI TODD A FEHNIGER · 2013 to 2026
$31.6M
TRANSLATING NK CELL BIOLOGY INTO CLINICAL CANCER IMMUNOTHERAPYR01CA205239 · NCI · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2017 to 2020
$2.4M
Defining the Complosome in Human Cells, Tissues and Disease StatesR35GM136352 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2020 to 2024
$2.0M
PLURIPOTENT STEM CELL-BASED IMMUNOTHERAPIESR21AI132910 · NIAID · UNIVERSITY OF ARIZONA · PI BHATTACHARYA, DEEPTA · 2018 to 2019
$435k
NCI NIH HHS P50 CA171963NCI NIH HHS R01 CA205239NIAID NIH HHS R21 AI132910NIGMS NIH HHS R35 GM136352
6 · The paper itself

Abstract

Allogeneic human pluripotent stem cell (hPSC)-derived cells and tissues for therapeutic transplantation must necessarily overcome immunological rejection by the recipient. To define these barriers and to create cells capable of evading rejection for preclinical testing in immunocompetent mouse models, we genetically ablated

Identifiers

PMID37425790
PMCPMC10326974
OpenAlexW4382517343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.