Evidence map›Paper›PMID 37425781›Full record

ArticlebioRxiv : the preprint server for biology2023

Simultaneous Multi-Omics Analysis by Direct Infusion Mass Spectrometry (SMAD-MS).

Yuming Jiang, Ivan Salladay-Perez, Amanda Momenzadeh, Anthony J Covarrubias, Jesse G Meyer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yuming JiangDepartment of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Ivan Salladay-PerezDepartment of Molecular Biology, Immunology, and Molecular Genetics, University of California, Los Angeles, 90095, USA.
Amanda MomenzadehDepartment of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Anthony J CovarrubiasDepartment of Molecular Biology, Immunology, and Molecular Genetics, University of California, Los Angeles, 90095, USA.
Jesse G MeyerDepartment of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.

Funding

Democratizing Multi-Omics to Expedite Discovery of Hidden Metabolic PathwaysR35GM142502 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI MEYER, JESSE · 2021 to 2025
$2.2M
Drug Discovery for Alzheimer’s Disease Enabled by Multi-Omics and Artificial IntelligenceR21AG074234 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI MEYER, JESSE · 2021 to 2022
$443k
NIA NIH HHS R21 AG074234NIGMS NIH HHS R35 GM142502
6 · The paper itself

Abstract

Combined multi-omics analysis of proteomics, polar metabolomics, and lipidomics requires separate liquid chromatography-mass spectrometry (LC-MS) platforms for each omics layer. This requirement for different platforms limits throughput and increases costs, preventing the application of mass spectrometry-based multi-omics to large scale drug discovery or clinical cohorts. Here, we present an innovative strategy for simultaneous multi-omics analysis by direct infusion (SMAD) using one single injection without liquid chromatography. SMAD allows quantification of over 9,000 metabolite

Identifiers

PMID37425781
PMCPMC10326973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.