ArticlebioRxiv : the preprint server for biology2023
Homologous mutations in
Chao Liu, Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J Agostino, Greg R Bowman, Kathleen M Ruppel, James A Spudich, Leslie A Leinwand
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 5 institutions in 1 country.
Chao LiuDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
Anastasia KarabinaBioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303.
Artur MellerDepartment of Biochemistry and Biophysics, Washington University in St. Louis, St. Louis, MO 63110.
Ayan BhattacharjeeDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Colby J AgostinoDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Greg R BowmanDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Kathleen M RuppelDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
James A SpudichDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
Leslie A LeinwandBioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303.
University of Pennsylvania · USCardiovascular Institute of the South · USUniversity of Colorado Boulder · USLawrence Livermore National Laboratory · USWashington University in St. Louis · US
Funding
MYOSIN MOVEMENT IN VITRO: MOLECULAR CHARACTERIZATIONR01GM033289 · NIGMS · STANFORD UNIVERSITY · PI SPUDICH, JAMES · 1985 to 2024
$13.6MMYOSIN GENE DIVERSITY AND FUNCTIONR01GM029090 · NIGMS · YESHIVA UNIVERSITY · PI Leslie Anne Leinwand · 1985 to 2026
$12.3MFrom proteins to cells to tissues: A multi-scale assessment of biomechanical regulation by the myosin molecular motorRM1GM131981 · NIGMS · STANFORD UNIVERSITY · PI BERNSTEIN, DANIEL, MACK, DAVID LEE · 2019 to 2023
$10.3MPOSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2MMolecular Characterization of Cardiomyopathy Mutations in Human Cardiac MyosinR01HL117138 · NHLBI · UNIVERSITY OF COLORADO · PI LEINWAND, LESLIE ANNE, PERKINS, THOMAS TUPPER · 2013 to 2021
$4.2MMSMs, adaptive sampling, and data sharing on the cloudR01GM124007 · NIGMS · WASHINGTON UNIVERSITY · PI BOWMAN, GREGORY · 2017 to 2021
$2.0MStructural basis for ApoE4-induced Alzheimer's diseaseRF1AG067194 · NIA · WASHINGTON UNIVERSITY · PI BOWMAN, GREGORY · 2021 to 2021
$1.8MShared TIRF and Patterned Illumination Fluorescence MicroscopeS10RR026775 · NCRR · STANFORD UNIVERSITY · PI STRAIGHT, AARON F · 2010 to 2010
$465kModeling Hidden Myosin Structural States to Predict Drug Specificity and Disease PhenotypesF30HL162431 · NHLBI · WASHINGTON UNIVERSITY · PI MELLER, ARTUR · 2022 to 2025
$141kNCRR NIH HHS S10 RR026775NHLBI NIH HHS F30 HL162431NHLBI NIH HHS R01 HL117138NHLBI NIH HHS T32 HL007822NIA NIH HHS RF1 AG067194NIGMS NIH HHS R01 GM029090NIGMS NIH HHS R01 GM033289NIGMS NIH HHS R01 GM124007NIGMS NIH HHS RM1 GM131981
6 · The paper itselfAbstract
Mutations at a highly conserved homologous residue in three closely related muscle myosins cause three distinct diseases involving muscle defects: R671C in
Indexed as
developmental skeletal myosinsenzyme kineticsforce sensitivityFreeman Sheldon syndromehypertrophic cardiomyopathyin vitro motilitymolecular dynamics simulationoptical tweezersstep sizetrismus-pseudocamptodactyly syndromeβ-cardiac myosin
Identifiers
PMID37425764
PMCPMC10327197
OpenAlexW4382893381
What OpenQuestion holds
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