Evidence map›Paper›PMID 37425751›Full record

ArticlebioRxiv : the preprint server for biology2023

Novel mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibition.

Christine W Gao, WanYing Lin, Ryan C Riddle, Priyanka Kushwaha, Leandros Boukas, Hans T Björnsson, Kasper D Hansen, Jill A Fahrner

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Christine W GaoDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
WanYing LinDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Ryan C RiddleDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Priyanka KushwahaDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Leandros BoukasDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Hans T BjörnssonDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Kasper D HansenDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Jill A FahrnerDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Johns Hopkins University · USReykjavík University · ISUniversity of Maryland, Baltimore · US

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Exploring Disrupted H3K27me3 in Mendelian Disorders of the Epigenetic Machinery and Restoring Its Balance as a Therapeutic Approach to Treat Abnormal GrowthK08HD086250 · NICHD · JOHNS HOPKINS UNIVERSITY · PI FAHRNER, JILL A · 2018 to 2023
$966k
Endocrine Actions of SclerostinI01BX003724 · VA · BALTIMORE VA MEDICAL CENTER · PI RIDDLE, RYAN C · 2017 to 2025
–
BLRD VA I01 BX003724NICHD NIH HHS K08 HD086250NIGMS NIH HHS T32 GM136577Wellcome Trust
6 · The paper itself

Abstract

Weaver syndrome is a Mendelian disorder of the epigenetic machinery (MDEM) caused by germline pathogenic variants in

Identifiers

PMID37425751
PMCPMC10327066
OpenAlexW4382048995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.