Evidence map›Paper›PMID 37425737›Full record

ArticlebioRxiv : the preprint server for biology2023

Early resource scarcity causes cortical astrocyte enlargement and sex-specific changes in the orbitofrontal cortex transcriptome in adult rats.

Claire Deckers, Reza Karbalaei, Nylah A Miles, Eden V Harder, Emily Witt, Erin P Harris, Kathryn Reissner, Mathieu E Wimmer, Debra A Bangasser

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Claire DeckersDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia.
Reza KarbalaeiDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia.
Nylah A MilesDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia.
Eden V HarderDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Emily WittDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Erin P HarrisNeuroscience Institute, Georgia State University, Atlanta.
Kathryn ReissnerDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Mathieu E WimmerDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia.
Debra A BangasserDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia.
Temple University · USUniversity of North Carolina at Chapel Hill · USGeorgia State University · US

Funding

Delineating the epigenetic and neural mechanisms by which early life scarcity alters motivated behaviorR01DA056534 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI Debra A Bangasser, Mathieu Wimmer · 2022 to 2026
$3.2M
Sex Differences In Stress Inoculation Of Addiction-Like PhenotypesR01DA049837 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI BANGASSER, DEBRA A · 2020 to 2024
$3.1M
Cell-specific epigenetic and transcriptomic signatures of impulsivity and its regulation by stress in the nucleus accumbensR21DA055846 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI BANGASSER, DEBRA A, REINER, BENJAMIN CHARLES · 2023 to 2024
$469k
Discriminating hormonal and sex chromosomal origins of sex differences in the septohippocampal circuitR21MH129020 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI BANGASSER, DEBRA A, YANG, XIA · 2022 to 2023
$430k
NIDA NIH HHS R01 DA049837NIDA NIH HHS R01 DA056534NIDA NIH HHS R21 DA055846NIMH NIH HHS R21 MH129020
6 · The paper itself

Abstract

Astrocyte morphology affects function, including the regulation of glutamatergic signaling. This morphology changes dynamically in response to the environment. However, how early life manipulations alter adult cortical astrocyte morphology is underexplored. Our lab uses brief postnatal resource scarcity, the limited bedding and nesting (LBN) manipulation, in rats. We previously found that LBN promotes later resilience to adult addiction-related behaviors, reducing impulsivity, risky decision-making, and morphine self-administration. These behaviors rely on glutamatergic transmission in the medial orbitofrontal (mOFC) and medial prefrontal (mPFC) cortex. Here we tested whether LBN changed astrocyte morphology in the mOFC and mPFC of adult rats using a novel viral approach that, unlike traditional markers, fully labels astrocytes. Prior exposure to LBN causes an increase in the surface area and volume of astrocytes in the mOFC and mPFC of adult males and females relative to control-raised rats. We next used bulk RNA sequencing of OFC tissue to assess transcriptional changes that could increase astrocyte size in LBN rats. LBN caused mainly sex-specific changes in differentially expressed genes. However,

Indexed as

cortexgliaglutamatemorphologysex differencesstress

Identifiers

PMID37425737
PMCPMC10327175
OpenAlexW4382893552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.