Evidence map›Paper›PMID 37425736›Full record

ArticlebioRxiv : the preprint server for biology2023

Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity.

Meghan L Bucher, Amy R Dunn, Joshua M Bradner, Kristen Stout Egerton, James P Burkett, Michelle A Johnson, Gary W Miller

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Meghan L BucherDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Amy R DunnDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Joshua M BradnerDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Kristen Stout EgertonDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
James P BurkettDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Michelle A JohnsonDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Gary W MillerDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Emory University · USColumbia University · US

Funding

Supplemental Training in Making Data FAIR and AI/ML ReadyT32ES007322 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Pam R Factor-Litvak, Allison Kupsco · 2000 to 2026
$12.1M
Vesicular Modulation of Dopamine Neuron ToxicityR01ES023839 · NIEHS · EMORY UNIVERSITY · PI MILLER, GARY W · 2015 to 2025
$5.0M
Synaptic vesicle glycoprotein 2C (SV2C) and psychostimulant actionsU18DA052498 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, GARY W · 2020 to 2020
$242k
SV2C as a novel mediator of transmitter release and neuroprotection in dopamine cellsF31NS089242 · NINDS · EMORY UNIVERSITY · PI DUNN, AMY · 2015 to 2017
$93k
SV2C: a novel target for inhibition of methamphetamine actionF31DA037652 · NIDA · EMORY UNIVERSITY · PI STOUT, KRISTEN · 2014 to 2015
$86k
NIDA NIH HHS F31 DA037652NIDA NIH HHS U18 DA052498NIEHS NIH HHS R01 ES023839NIEHS NIH HHS T32 ES007322NINDS NIH HHS F31 NS089242
6 · The paper itself

Abstract

Dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high energy demand, and broad unmyelinated axonal arborizations. Impairments in the storage of dopamine compound this stress due to cytosolic reactions that transform the vital neurotransmitter into an endogenous neurotoxicant, and this toxicity is thought to contribute to the dopamine neuron degeneration that occurs Parkinson's disease. We have previously identified synaptic vesicle glycoprotein 2C (SV2C) as a modifier of vesicular dopamine function, demonstrating that genetic ablation of SV2C in mice results in decreased dopamine content and evoked dopamine release in the striatum. Here, we adapted a previously published

Identifiers

PMID37425736
PMCPMC10326994
OpenAlexW4382049692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.