Evidence map›Paper›PMID 37425721›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Online speech synthesis using a chronically implanted brain-computer interface in an individual with ALS.

Miguel Angrick, Shiyu Luo, Qinwan Rabbani, Daniel N Candrea, Samyak Shah, Griffin W Milsap, William S Anderson, Chad R Gordon, Kathryn R Rosenblatt, Lora Clawson and 6 more

Registry-linked trialOpen access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03567213 (Investigation on the Cortical Communication), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03567213 narecruitingnot on this map

Investigation on the Cortical Communication (CortiCom) System

TypeinterventionalSponsorJohns Hopkins UniversityRan2021 to 2030Enrolled3ConditionsTetraplegia, Locked-in Syndrome, Brainstem Stroke, Amyotrophic Lateral SclerosisArmsSurgical implantation of CortiCom system
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 20 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Miguel AngrickDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shiyu LuoDepartment of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Qinwan RabbaniDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, USA.
Daniel N CandreaDepartment of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Samyak ShahDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Griffin W MilsapResearch and Exploratory Development Department, Johns Hopkins Applied Physics Laboratory, Laurel, MD, USA.
William S AndersonDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD.
Chad R GordonDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD.
Kathryn R RosenblattDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lora ClawsonDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicholas MaragakisDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Francesco V TenoreResearch and Exploratory Development Department, Johns Hopkins Applied Physics Laboratory, Laurel, MD, USA.
Matthew S FiferResearch and Exploratory Development Department, Johns Hopkins Applied Physics Laboratory, Laurel, MD, USA.
Hynek HermanskyCenter for Language and Speech Processing, The Johns Hopkins University, Baltimore, MD, USA.
Nick F RamseyUMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Nathan E CroneDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins University Applied Physics Laboratory · USUniversity Medical Center Utrecht · NL

Funding

Investigation of the Cortical Communication (CORTICOM) SystemUH3NS114439 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CRONE, NATHAN E, RAMSEY, NICOLAS FRANCISCUS · 2020 to 2025
$6.6M
NINDS NIH HHS UH3 NS114439
6 · The paper itself

Abstract

Recent studies have shown that speech can be reconstructed and synthesized using only brain activity recorded with intracranial electrodes, but until now this has only been done using retrospective analyses of recordings from able-bodied patients temporarily implanted with electrodes for epilepsy surgery. Here, we report online synthesis of intelligible words using a chronically implanted brain-computer interface (BCI) in a clinical trial participant (ClinicalTrials.gov, NCT03567213) with dysarthria due to amyotrophic lateral sclerosis (ALS). We demonstrate a reliable BCI that synthesizes commands freely chosen and spoken by the user from a vocabulary of 6 keywords originally designed to allow intuitive selection of items on a communication board. Our results show for the first time that a speech-impaired individual with ALS can use a chronically implanted BCI to reliably produce synthesized words that are intelligible to human listeners while preserving the participants voice profile.

Identifiers

PMID37425721
PMCPMC10327279
OpenAlexW4382793422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.