Evidence map›Paper›PMID 37425706›Full record

ArticleResearch square2023

Determining structures of individual RNA conformers using atomic force microscopy images and deep neural networks.

Maximilia F S Degenhardt, Hermann F Degenhardt, Yuba R Bhandari, Yun-Tzai Lee, Jienyu Ding, William F Heinz, Jason R Stagno, Charles D Schwieters, Jinwei Zhang, Yun-Xing Wang

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Maximilia F S DegenhardtProtein-Nucleic Acid Interaction Section, Center for Structural Biology, National Cancer Institute; Frederick, USA.
Hermann F DegenhardtProtein-Nucleic Acid Interaction Section, Center for Structural Biology, National Cancer Institute; Frederick, USA.
Yuba R BhandariProtein-Nucleic Acid Interaction Section, Center for Structural Biology, National Cancer Institute; Frederick, USA.
Yun-Tzai LeeProtein-Nucleic Acid Interaction Section, Center for Structural Biology, National Cancer Institute; Frederick, USA.ORCID 0000-0001-8123-6207
Jienyu DingProtein-Nucleic Acid Interaction Section, Center for Structural Biology, National Cancer Institute; Frederick, USA.
William F HeinzOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0002-6194-0536
Jason R StagnoProtein-Nucleic Acid Interaction Section, Center for Structural Biology, National Cancer Institute; Frederick, USA.ORCID 0000-0002-6464-7829
Charles D SchwietersComputational Biomolecular Magnetic Resonance Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; Bethesda, USA.ORCID 0000-0002-4216-4658
Jinwei ZhangStructural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; Bethesda, USA.ORCID 0000-0002-2114-173X
Yun-Xing WangProtein-Nucleic Acid Interaction Section, Center for Structural Biology, National Cancer Institute; Frederick, USA.ORCID 0000-0002-2175-0148

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCI NIH HHS 75N91019D00024
6 · The paper itself

Abstract

The vast percentage of the human genome is transcribed into RNA, many of which contain various structural elements and are important for functions. RNA molecules are conformationally heterogeneous and functionally dyanmics

Identifiers

PMID37425706
PMCPMC10327248

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.