ArticlemedRxiv : the preprint server for health sciences2023
Early life seizures and epileptic spasms in
Kim M Thalwitzer, Julie Xian, Danielle deCampo, Shridhar Parthasarathy, Jan Magielski, Katie Rose Sullivan, James Goss, Charlene Son Rigby, Michael Boland, Ben Prosser and 3 more
Open access · greenAbstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors at 2 institutions in 2 countries.
Kim M ThalwitzerDivision of Neurology, Children's Hospital of Philadelphia, USA.
Julie XianDivision of Neurology, Children's Hospital of Philadelphia, USA.
Danielle deCampoThe Epilepsy NeuroGenetics Initiative (ENGIN), Children's Hospital of Philadelphia, USA.
Shridhar ParthasarathyDivision of Neurology, Children's Hospital of Philadelphia, USA.
Jan MagielskiDivision of Neurology, Children's Hospital of Philadelphia, USA.
Katie Rose SullivanDivision of Neurology, Children's Hospital of Philadelphia, USA.
James GossSTXBP1 Foundation, USA.
Charlene Son RigbySTXBP1 Foundation, USA.
Michael BolandEpilepsy and Neurodevelopmental Disorders Center (ENDD), Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, USA.
Ben ProsserDepartment of Physiology, University of Pennsylvania Perelman School of Medicine, USA.
Sarah M RuggieroDivision of Neurology, Children's Hospital of Philadelphia, USA.
Steffen SyrbeDivision of Pediatric Epileptology, Center for Pediatrics and Adolescent Medicine, University Hospital Heidelberg, Germany.
Children's Hospital of Philadelphia · USHeidelberg University · DE
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MThe Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3MA computational phenotyping approach to characterize neurogenetic disordersR01NS131512 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Ingo Helbig · 2023 to 2026
$2.8MSubgroup delineation in genetic epilepsies and developmental brain disordersR01NS127830 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Ingo Helbig · 2023 to 2026
$2.8MJoint analysis of genomic and electronic medical record data to assess outcomes and drug response in pediatric epilepsiesK02NS112600 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI HELBIG, INGO · 2020 to 2024
$963kNCATS NIH HHS UL1 TR001878NICHD NIH HHS U54 HD086984NINDS NIH HHS K02 NS112600NINDS NIH HHS R01 NS127830NINDS NIH HHS R01 NS131512
6 · The paper itselfAbstract
Background and Objectives: Individuals with disease-causing variants in Methods: We retrospectively reconstructed seizure and medication histories in weekly intervals for individuals with Results: We included 61 individuals with early onset seizures, 29 of whom had epileptic spasms. Individuals with neonatal seizures were likely to have continued seizures after the neonatal period (25/26). The risk of developing epileptic spasms was not increased in individuals with neonatal seizures or early infantile seizures (21/41 vs. 8/16; OR 1, 95% CI 0.3-3.9, Discussion: We provide a comprehensive assessment of early-onset seizures in
Indexed as
Developmental and epileptic encephalopathyepilepsyinfantile spasmsneonatal seizuresSTXBP1-related disorders
Identifiers
PMID37425705
PMCPMC10327252
OpenAlexW4382395334
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390