ArticleFrontiers in medicine2023
Leprosy among children in an area without primary health care coverage in Caratateua Island, Brazilian Amazon.
Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Vitiligo and Its Mimics in Childhood: A Diagnostic Framework for Hypopigmented Disorders.Annals of dermatology · 2026Review
- Transmission Interruption of Leprosy in the Philippines: An Update on the Current Program Priorities and Interventions.Tropical medicine and infectious disease · 2026Article
- Leprosy in blood donors.Tropical medicine & international health : TM & IH · 2025Article
- Agglomerative hierarchical cluster analysis and temporal trend of leprosy indicators in Brazilian states, 2012-2022.Memorias do Instituto Oswaldo Cruz · 2025Article
- Participatory development of Indonesia's national action plan for zero leprosy: strategies and interventions.Frontiers in public health · 2025Article
- Progression of the leprosy reaction and nerve damage: A prospective cohort study in children with leprosy from the Brazilian Amazon.PLoS neglected tropical diseases · 2024Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
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Abstract
Introduction: The detection of leprosy in children is an important epidemiological marker of the disease, indicating the community's early exposure to Methods: In order to detect new cases among children by combining clinical evaluation and laboratory tests, we conducted an active case finding among individuals under 15 years old on Caratateua Island, located in the city of Belém, in the Pará state, an endemic region in the Amazon. Dermato-neurological examination, collection of 5 mL of peripheral blood for IgM anti-PGL-I antibody titration, and intradermal scraping for bacilloscopy and amplification of the specific RLEP region by qPCR were performed. Results: Out of the 56 examined children, 28/56 (50%) new cases were identified. At the time of evaluation, 38/56 (67.8%) children presented one or more clinical alterations. Seropositivity was detected in 7/27 (25.9%) new cases and 5/24 (20.8%) undiagnosed children. DNA amplification of Discussion: Our research detected a number of cases 5.6 times higher compared to the total number of pediatric cases recorded throughout the year 2021 in the municipality of Belém, which shows a critical scenario of underdiagnosing of leprosy among children under 15 years old in the region. We propose the use of qPCR technique to identify new cases among children with oligosymptomatic or early disease in endemic areas, in addition to the training of Primary Health Care professionals and the implementation of the Family Health Strategy coverage in the visited area.
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