Evidence map›Paper›PMID 37425298›Full record

ArticleFrontiers in medicine2023

Torque teno virus viremia and QuantiFERON

Sarah Mafi, Marie Essig, Jean-Philippe Rerolle, Gisèle Lagathu, Romain Crochette, Véronique Brodard, Betoul Schvartz, Stephanie Gouarin, Nicolas Bouvier, Ilka Engelmann and 12 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02064699 (Assessing the Risk of CMV Infection of the Renal Transplant About R + by Cellular Immunity Analyzed by the QuantiFERON ®-CMV Test.), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02064699 terminatednot on this map

Assessing the Risk of CMV Infection of the Renal Transplant About R + by Cellular Immunity Analyzed by the QuantiFERON ®-CMV Test.

TypeobservationalSponsorUniversity Hospital, LimogesRan2013 to 2017Enrolled75ConditionsRenal Transplant Recipient, Immunized Against the CytomegalovirusArmsCMV Infection
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 1 country.

Sarah MafiFrench National Reference Center for Herpesviruses, Bacteriology, Virology, Hygiene Department, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Marie EssigNephrology and Transplantation Department, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Jean-Philippe RerolleNephrology and Transplantation Department, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Gisèle LagathuVirology Department, Centre Hospitalier Universitaire de Rennes, Rennes, France.
Romain CrochetteNephrology and Transplantation Department, Centre Hospitalier Universitaire de Rennes, Rennes, France.
Véronique BrodardVirology Department, Centre Hospitalier Universitaire de Reims, Reims, France.
Betoul SchvartzNephrology and Transplantation Department, Centre Hospitalier Universitaire de Reims, Reims, France.
Stephanie GouarinVirology Department, Centre Hospitalier Universitaire de Caen, Caen, France.
Nicolas BouvierNephrology and Transplantation Department, Centre Hospitalier Universitaire de Caen, Caen, France.
Ilka EngelmannVirology Department, Centre Hospitalier Universitaire de Lille, Lille, France.
Antoine GarstkaNephrology and Transplantation Department, Centre Hospitalier Universitaire de Lille, Lille, France.
Céline Bressollette-BodinVirology Department, Centre Hospitalier Universitaire de Nantes, Nantes, France.
Diego CantarovitchNephrology and Transplantation Department, Centre Hospitalier Universitaire de Nantes, Nantes, France.
Raphaële GermiVirology Department, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.
Benedicte JanbonNephrology and Transplantation Department, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.
Christine ArchimbautVirology Department, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.
Anne-Elizabeth HengNephrology and Transplantation Department, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.
Françoise GarnierFrench National Reference Center for Herpesviruses, Bacteriology, Virology, Hygiene Department, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Melissa Gomes-MayerasFrench National Reference Center for Herpesviruses, Bacteriology, Virology, Hygiene Department, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Anaïs LabrunieBiostatistics Department, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Sébastien HantzFrench National Reference Center for Herpesviruses, Bacteriology, Virology, Hygiene Department, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Sophie AlainFrench National Reference Center for Herpesviruses, Bacteriology, Virology, Hygiene Department, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Centre Hospitalier Universitaire de Limoges · FRInserm · FRCentre Hospitalier Universitaire de Caen · FRCentre Hospitalier Universitaire de Clermont-Ferrand · FRCentre Hospitalier Universitaire de Lille · FRCentre Hospitalier Universitaire de Nantes · FRCentre Hospitalier Universitaire de Rennes · FRUniversité de Reims Champagne-Ardenne · FRUniversité Grenoble Alpes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cytomegalovirus (CMV) is the most frequent infectious complication following solid organ transplantation. Torque teno viruses (TTV) viremia has been proposed as a biomarker of functional immunity in the management of kidney transplant recipients (KTR). The QuantiFERON Methods: In a prospective national multicenter cohort of 64 CMV-seropositive (R+) KTR, we analyzed the value of TTV load and the two markers of the QF-CMV assay [QF-Ag (CMV-specific T-cell responses) and QF-Mg (overall T-cell responses)], alone and in combination, in prediction of CMV reactivation (≥3 log Results: Using the conventional cut-off (3.45 log Conclusion: The combination of TTV load and QF-Ag or TTV load and QF-Mg could be useful in stratifying the risk of CMV reactivation in R+ KTR during the first post-transplant year and thereby have an impact on the duration of prophylaxis in these patients. Clinical trial registration: ClinicalTrials.gov registry, identifier NCT02064699.

Indexed as

CMV-seropositive recipientscytomegaloviruskidney transplantationQuantiFERON® CMVTorquetenovirus

Identifiers

PMID37425298
PMCPMC10323437
OpenAlexW4381683543

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.