Evidence map›Paper›PMID 37425048›Full record

ArticleActa pharmaceutica Sinica. B2023

Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis.

Qian Yu, Chang Li, Qinghui Niu, Jigang Wang, Zhaodi Che, Ke Lei, He Ren, Boyi Ma, Yixing Ren, Pingping Luo and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Qian YuTumor Immunology and Cytotherapy of Medical Research Center, and Center for GI Cancer Diagnosis and Treatment, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Chang LiBau Institute of Medical and Health Sciences Education and School of Biomedical Sciences, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong 999077, China.
Qinghui NiuDepartment of Liver Center, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Jigang WangDepartment of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Zhaodi CheClinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Ke LeiTumor Immunology and Cytotherapy of Medical Research Center, and Center for GI Cancer Diagnosis and Treatment, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
He RenTumor Immunology and Cytotherapy of Medical Research Center, and Center for GI Cancer Diagnosis and Treatment, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Boyi MaTumor Immunology and Cytotherapy of Medical Research Center, and Center for GI Cancer Diagnosis and Treatment, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Yixing RenDepartment of General Surgery, and Institute of Hepato-Biliary-Pancreas and Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Pingping LuoClinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Zhuming FanBau Institute of Medical and Health Sciences Education and School of Biomedical Sciences, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong 999077, China.
Huan ZhangDepartment of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hong Kong 999077, China.
Zhaohui LiuSchool of Biomedical Sciences, the Chinese University of Hong Kong, Hong Kong 999077, China.
George L TipoeBau Institute of Medical and Health Sciences Education and School of Biomedical Sciences, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong 999077, China.
Jia XiaoClinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Qingdao University · CNAffiliated Hospital of North Sichuan Medical College · CNChinese University of Hong Kong · HKFirst Affiliated Hospital of Jinan University · CNUniversity of Hong Kong · HKHong Kong Polytechnic University · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis (NASH) remain largely unknown. We aimed to elucidate the roles of hepatic cyclooxygenase 1 (COX1) in autophagy and the pathogenesis of diet-induced steatohepatitis in mice. Human nonalcoholic fatty liver disease (NAFLD) liver samples were used to examine the protein expression of COX1 and the level of autophagy.

Indexed as

Autophagosome maturationAutophagyCyclooxygenase 1InflammationLipid metabolismNonalcoholic fatty liver diseasePhosphatidylinositol 3-phosphatePhosphoinositide interacting 2WD repeat domain

Identifiers

PMID37425048
PMCPMC10326296
OpenAlexW4323852690

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.