Evidence map›Paper›PMID 37425036›Full record

ArticleActa pharmaceutica Sinica. B2023

Manipulation of IME4 expression, a global regulation strategy for metabolic engineering in

Jianxun Zhu, Tianyue An, Wenlong Zha, Ke Gao, Ting Li, Jiachen Zi

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Characterization of two key cytochrome P450 enzymes inSynthetic and systems biotechnology · 2027
    Article
  2. Construction of a globally modular recombinantSynthetic and systems biotechnology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Genome-Wide Identification and Expression Analysis of mInternational journal of molecular sciences · 2025
    Article
  7. Introduction of human mMicrobial cell factories · 2025
    Article
  8. Review
  9. Microbial production of 5-Applied and environmental microbiology · 2024
    Article
  10. Human Sterols Are Overproduced, Stored and Excreted in Yeasts.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jianxun ZhuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Tianyue AnCollege of Pharmacy, Jinan University, Guangzhou 510632, China.
Wenlong ZhaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Ke GaoCollege of Pharmacy, Jinan University, Guangzhou 510632, China.
Ting LiCollege of Pharmacy, Jinan University, Guangzhou 510632, China.
Jiachen ZiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic engineering has been widely used for production of natural medicinal molecules. However, engineering high-yield platforms is hindered in large part by limited knowledge of complex regulatory machinery of metabolic network.

Indexed as

Aromatic compoundsIsoprenoidsMetabolic engineeringRNA m6A modificationSaccharomyces cerevisiae

Identifiers

PMID37425036
PMCPMC10326246
OpenAlexW4313856396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.