ArticleFrontiers in neuroscience2023
Disrupted topological organization of white matter structural networks in high myopia patients revealed by diffusion kurtosis imaging and tractography.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- White matter microstructure and structural network alterations in children with global developmental delay.Pediatric research · 2026Article
- Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis.Investigative ophthalmology & visual science · 2025Observational
- Association Between Glaucoma and Brain Structural Connectivity Based on Diffusion Tensor Tractography: A Bidirectional Mendelian Randomization Study.Brain sciences · 2024Article
- Analyzing the topological properties of resting-state brain function network connectivity based on graph theoretical methods in patients with high myopia.BMC ophthalmology · 2024Article
- Diffusion kurtosis imaging tractography reveals disrupted white matter structural networks in children with obstructive sleep apnea syndrome.Brain imaging and behavior · 2024Article
- Screening of genes interacting with high myopia and neuropsychiatric disorders.Scientific reports · 2023Article
- Exploration of spontaneous brain activity abnormalities in high myopia patients using resting-state fMRI with multiparameter analysis.Frontiers in neurologyArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
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Abstract
Introduction: High myopia (HM) is a public health issue that can lead to severe visual impairment. Previous studies have exhibited widespread white matter (WM) integrity damage in HM patients. However, how these WM damages are topologically related, and the network-level structural disruptions underlying HM has not been fully defined. We aimed to assess the alterations of brain WM structural networks in HM patients using diffusion kurtosis imaging (DKI) and tractography in the present study. Methods: Individual whole-brain and ROI-level WM networks were constructed using DKI tractography in 30 HM patients and 33 healthy controls. Graph theory analysis was then applied to explore the altered global and regional network topological properties. Pearson correlations between regional properties and disease duration in the HM group were also assessed. Results: For global topology, although both groups showed a small-world network organization, HM patients exhibited significant decreased local efficiency and clustering coefficient compared with controls. For regional topology, HM patients and controls showed highly similar hub distributions, except for three additional hub regions in HM patients including left insula, anterior cingulate and paracingulate gyri (ACG), and median cingulate and paracingulate gyri (DCG). In addition, HM patients showed significantly altered nodal betweenness centrality (BC) mainly in the bilateral inferior occipital gyrus (IOG), left superior occipital gyrus (SOG), caudate nucleus, rolandic operculum and right putamen, pallidum, and gyrus rectus compared with controls. Intriguingly, the nodal BC of left IOG was negatively correlated with disease duration in HM patients. Discussion: Our findings suggest that HM exhibited alterations in WM structural networks as indicated by decreased local specialization. This study may advance the current understanding of the pathophysiological mechanisms underlying HM.
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