Evidence map›Paper›PMID 37424817›Full record

ArticleAmerican journal of cancer research2023

Claudin 4 enhances the malignancy of glioma cells via NNAT/Wnt signaling.

Feilong Yang, Wuhuan Xu, Xielin Tang, Qianke Li, Xiaolin Hou, Xuhui Hui

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Feilong YangDepartment of Neurosurgery, West China Hospital, Sichuan University Chengdu, Sichuan, China.
Wuhuan XuDepartment of Neurology, The Affiliated Santai Hospital of North Sichuan Medical College Mianyang, Sichuan, China.
Xielin TangDepartment of Neurosurgery, The Affiliated Santai Hospital of North Sichuan Medical College Mianyang, Sichuan, China.
Qianke LiDepartment of Neurosurgery, The Affiliated Santai Hospital of North Sichuan Medical College Mianyang, Sichuan, China.
Xiaolin HouDepartment of Neurosurgery, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Chengdu, Sichuan, China.
Xuhui HuiDepartment of Neurosurgery, West China Hospital, Sichuan University Chengdu, Sichuan, China.
Sichuan Mianyang 404 Hospital · CNSichuan University · CNChengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliomas are the most common malignancies of the central nervous system and are associated with high mortality rates. However, the pathogenesis of gliomas is unclear. In this study, we show that elevated claudin-4 (CLDN4) levels in glioma tissues are associated with poor clinical outcomes. We found that upregulating the expression of CLND4 enhanced the proliferative and migratory capacities of glioma cells. Mechanistically, CLND4 upregulated Neuronatin (NNAT) by activating Wnt3A signaling, and aided in the progression of the glioma. Most importantly, our

Indexed as

Claudin 4 (CLDN4)gliomaneuronatin (NNAT)Wnt signaling

Identifiers

PMID37424817
PMCPMC10326589
OpenAlexW4383711327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.