Evidence map›Paper›PMID 37424517›Full record

ArticlePediatric transplantation2023

Extracorporeal membrane oxygenation bridge to pediatric lung transplantation: Modern era analysis.

Wonshill Koh, Huaiyu Zang, Nicholas J Ollberding, Assem Ziady, Don Hayes

Abstract read
In one paragraph

Article in Pediatric transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pediatric lung transplantation in China, 2019-2023.World journal of pediatrics : WJP · 2025
    Article
  7. Article
  8. Lung transplantation in children.Turk gogus kalp damar cerrahisi dergisi · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wonshill KohHeart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-6519-7743
Huaiyu ZangHeart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Nicholas J OllberdingDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Assem ZiadyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Don HayesHeart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-6734-6052

Funding

Imaging and Molecular Phenotyping of Cystic Fibrosis Lung DiseaseR01HL151588 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I, ZIADY, ASSEM G · 2021 to 2025
$3.9M
Predictive Molecular Markers of Lung Function DeclineR01HL142210 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI ZIADY, ASSEM G · 2019 to 2022
$1.7M
NHLBI NIH HHS R01 HL142210NHLBI NIH HHS R01 HL151588NIH HHS
6 · The paper itself

Abstract

backgroundSurvival outcomes of children on extracorporeal membrane oxygenation (ECMO) at time of lung transplant (LTx) remain unclear.

methodsPediatric first-time LTx recipients transplanted between January 2000 and December 2020 were identified in the United Network for Organ Sharing Registry to compare post-transplant survival according to ECMO support at time of transplant. For a comprehensive analysis of the data, univariate analysis, multivariable Cox regression, and propensity score matching were performed.

resultsDuring the study period, 954 children under 18 years of age underwent LTx with 40 patients on ECMO. We did not identify a post-LTx survival difference between patients receiving ECMO when compared to those that did not. A multivariable Cox regression model (Hazard ratio = 0.83; 95% confidence interval: 0.47, 1.45; p = .51) did not demonstrate an increased risk for death post-LTx. Lastly, a propensity score matching analysis, retaining 33 ECMO and 33 non-ECMO patients, further confirmed no post-LTx survival difference comparing ECMO to no ECMO cohorts (Hazard ratio = 0.98; 95% confidence interval: 0.48, 2.00; p = .96).

conclusionsIn this contemporary cohort of children, the use of ECMO at the time of LTx did not negatively impact post-transplant survival.

Indexed as

Extracorporeal Membrane OxygenationLung TransplantationAdolescentChildHumansProportional Hazards ModelsRetrospective StudiesTime FactorsTreatment Outcomeextracorporeal membrane oxygenation (ECMO) supportlung transplantpediatricspost-lung transplant survival

Identifiers

PMID37424517
PMCPMC10530187

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.