Article in EMBO reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors at 6 institutions in 4 countries.
Ruben Gomez-GutierrezDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-9134-4375
Ujjayini GhoshLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7818-4792
Wai-Ming YauLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Nazaret GamezDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Katherine DoDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-0390-2689
Carlos KrammDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-6113-3814
Hamid ShiraniDepartment of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.
Laura Vegas-GomezDpto. Biología Celular, Genética y Fisiología, Instituto de Investigación Biomédica de Málaga-IBIMA, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.ORCID 0000-0003-4823-5987
Jonathan SchulzDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Ines Moreno-GonzalezDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-3875-0889
Antonia GutierrezDpto. Biología Celular, Genética y Fisiología, Instituto de Investigación Biomédica de Málaga-IBIMA, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.ORCID 0000-0002-6264-6152
K Peter R NilssonDepartment of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.
Robert TyckoLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7039-7275
Claudio SotoDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-3412-0524
Rodrigo MoralesDepartment of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-7766-5770
The University of Texas Health Science Center at Houston · USInstituto de Investigación Biomédica de Málaga · ESNational Institutes of Health · USLinköping University · SEUniversidad Bernardo O'Higgins · CLBiomedical Research Networking Center on Neurodegenerative Diseases · ES
Funding
Research Resource for Human Organs and Tissues (U42)U42OD011158 · OD · NATIONAL DISEASE RESEARCH INTERCHANGE · PI BELL, THOMAS J · 2012 to 2025
$25.0M
Structural Studies of Alzheimer's beta-Amyloid FibrilsZIADK029061 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI TYCKO, ROBERT · 2009 to 2025
$8.4M
Role of circulating Abeta seeds and peripheral tissue damage in Alzheimer's disease pathogenesisRF1AG059321 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MORALES, RODRIGO, SOTO, CLAUDIO · 2020 to 2020
$2.9M
Infection-driven mechanisms associated with Alzheimer's disease pathologyRF1AG072491 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BARICHELLO, TATIANA, MORALES, RODRIGO · 2021 to 2021
$2.0M
Role of circulating Abeta seeds and peripheral tissue damage in Alzheimer's disease pathogenesisR01AG059321 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MORALES, RODRIGO, SOTO, CLAUDIO · 2024 to 2024
$718k
Structural Studies of Alzheimer's beta-Amyloid FibrilsZ01DK029061 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI TYCKO, ROBERT · 2007 to 2008
$671k
Isolation, characterization and pathogenic role of self-propagating conformational amyloid-beta strainsR56AG061878 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MORALES, RODRIGO, SOTO, CLAUDIO · 2018 to 2018
Misfolded Aβ is involved in the progression of Alzheimer's disease (AD). However, the role of its polymorphic variants or conformational strains in AD pathogenesis is not fully understood. Here, we study the seeding properties of two structurally defined synthetic misfolded Aβ strains (termed 2F and 3F) using in vitro and in vivo assays. We show that 2F and 3F strains differ in their biochemical properties, including resistance to proteolysis, binding to strain-specific dyes, and in vitro seeding. Injection of these strains into a transgenic mouse model produces different pathological features, namely different rates of aggregation, formation of different plaque types, tropism to specific brain regions, differential recruitment of Aβ
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice. · full record | OpenQuestion