Evidence map›Paper›PMID 37424464›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Ventricular Electrocardiographic Signatures Associated with Dementia and Plasma Alzheimer's Disease Biomarkers in Older Adults: A Population-Based Study.

Ming Mao, Chaoqun Wang, Tingting Hou, Xiaolei Han, Rui Liu, Qi Han, Yi Dong, Jiafeng Wang, Cuicui Liu, Lin Cong and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Ming MaoDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Chaoqun WangDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Tingting HouDepartment of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.
Xiaolei HanDepartment of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.
Rui LiuDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Qi HanDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Yi DongDepartment of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.
Jiafeng WangDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Cuicui LiuDepartment of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.
Lin CongDepartment of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.
Yume ImahoriAging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden.
Davide Liborio VetranoAging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden.
Yongxiang WangDepartment of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.
Yifeng DuDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Chengxuan QiuDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Shandong University · CNShandong Provincial Hospital · CNStockholm University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence has emerged that altered ventricular electrocardiogram profiles are associated with dementia, but the neuropathological mechanisms underlying their associations are poorly understood.

objectiveTo investigate the interrelationships of ventricular electrocardiogram profiles with dementia and plasma Alzheimer's disease (AD) biomarkers among older adults.

methodsThis population-based cross-sectional study included 5,153 participants (age ≥65 years; 57.3% women) living in rural communities in China; of these, 1,281 had data on plasma amyloid-β (Aβ)40, Aβ42, total-tau, and neurofilament light chain (NfL) protein. The QT, QTc, JT, JTc, QRS intervals, and QRS axis were derived from the 10-second electrocardiogram recording. The DSM-IV criteria were followed for clinical diagnosis of dementia, the NIA-AA criteria for AD, and the NINDS-AIREN criteria for vascular dementia (VaD). Data were analyzed using general linear models, multinomial logistic models, and restricted cubic splines.

resultsOf the 5,153 participants, 299 (5.8%) were diagnosed with dementia, including 194 with AD and 94 with VaD. Prolonged QT, QTc, JT, and JTc intervals were significantly associated with all-cause dementia, AD, and VaD (p < 0.05). Left QRS axis deviation was significantly associated with all-cause dementia and VaD (p < 0.01). In the subsample of plasma biomarkers (n = 1,281), prolonged QT, JT, and JTc intervals were significantly associated with a lower Aβ42/Aβ40 ratio and higher plasma NfL concentrations (p < 0.05).

conclusionAlterations in ventricular repolarization and depolarization are independently associated with all-cause dementia, AD, VaD, and AD plasma biomarkers in older adults (age ≥65 years). Ventricular electrocardiogram parameters may be valuable clinical markers for dementia and the underlying AD pathologies and neurodegeneration.

Indexed as

Alzheimer DiseaseHeart VentriclesAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersCardiovascular DiseasesDementiaElectrocardiographyFemaleHumansMaleAmyloid beta-PeptidesBiomarkersAlzheimer’s diseasedementiaelectrocardiogramneurodegenerationpopulation-based study

Identifiers

PMID37424464
PMCPMC10473117
OpenAlexW4383533258

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.