ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- A novel multifunctional split-type porous biomimetic absorbable mPLA-HA lamina for spinal posterior column reconstruction following laminectomy.Bioactive materials · 2026Article
- Bone microenvironment-driven macro-galvanic coupling of Zn alloys: Mediating immune response and osteogenesis.Bioactive materials · 2026Article
- Topology-Driven Mechanical Tuning of FDM-Printed TPU Tubular Lattices with Auxetic Architectures.Micromachines · 2026Article
- Biodegradable Magnesium-Based Implants in Sports Orthopedic Surgery: Advances in Alloy Design, Surface Engineering, and Translational Evidence.Bioengineering (Basel, Switzerland) · 2026Review
- A continuous adhesion-enhanced osteogenic pathway in artificial scaffold drives cellular infiltration and condensed mineralization for rapid bone regeneration.Bioactive materials · 2026Article
- Biodegradable Zn-Based Implants: Progress, Challenges, and Pathways toward Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Combining Fluid Dynamics and Biological Experiments to Explore the More Suitable Porosity for Bone Inducing Porous Tantalum Scaffolds.Orthopaedic surgery · 2026Article
- Metallic topological structures in bone repair implants: Design, properties, and biological interactions.Journal of orthopaedic translation · 2026Review
- Research on the regulation of osteogenic differentiation and mechanotransduction by porous bionic coatings on titanium alloy implant surfaces.RSC advances · 2026Article
- Sequential treatment of infectious bone defects with three dimensional-printed body temperature-responsive shape memory scaffold coated with metal-polyphenol layers.Burns & trauma · 2026Article
- Compositionally Optimized Bone Scaffolds Based on Carbonate Apatite and Silver Phosphate for Osteogenesis, Scaffold Resorption, and Photoactivated Antibacterial Activity.ACS applied bio materials · 2025Article
- Promoting implant osseointegration via the osteoblast-selective β-amino acid polymer strategy.Nature communications · 2025Article
- TiOACS applied materials & interfaces · 2025Article
- The effect of barium titanate-coated titanium alloy scaffolds on bone regeneration in osteonecrosis of the femoral head models: a comprehensive analysis based onFrontiers in bioengineering and biotechnology · 2025Article
- Article
- Vancomycin-encapsulated hydrogel loaded microarc-oxidized 3D-printed porous Ti6Al4V implant for infected bone defects: Reconstruction, anti-infection, and osseointegration.Bioactive materials · 2024Article
- Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms.Materials today. Bio · 2024Review
- Additively Manufactured Zn-2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Customized Additive Manufacturing in Bone Scaffolds-The Gateway to Precise Bone Defect Treatment.Research (Washington, D.C.) · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Additively manufactured scaffolds offer significant potential for treating bone defects, owing to their porous, customizable architecture and functionalization capabilities. Although various biomaterials have been investigated, metals - the most successful orthopedic material - have yet to yield satisfactory results. Conventional bio-inert metals, such as titanium (Ti) and its alloys, are widely used for fixation devices and reconstructive implants, but their non-bioresorbable nature and the mechanical property mismatch with human bones limit their application as porous scaffolds for bone regeneration. Advancements in additive manufacturing have facilitated the use of bioresorbable metals, including magnesium (Mg), zinc (Zn), and their alloys, as porous scaffolds via Laser Powder Bed Fusion (L-PBF) technology. This in vivo study presents a comprehensive, side-by-side comparative analysis of the interactions between bone regeneration and additively manufactured bio-inert/bioresorbable metal scaffolds, as well as their therapeutic outcomes. The research offers an in-depth understanding of the metal scaffold-assisted bone healing process, illustrating that Mg and Zn scaffolds contribute to the bone healing process in distinct ways, but ultimately deliver superior therapeutic outcomes compared to Ti scaffolds. These findings suggest that bioresorbable metal scaffolds hold considerable promise for the clinical treatment of bone defects in the near future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.