Evidence map›Paper›PMID 37424286›Full record

ArticleLab on a chip2023

Real-time imaging of nanobubble ultrasound contrast agent flow, extravasation, and diffusion through an extracellular matrix using a microfluidic model.

Michaela B Cooley, William J Wulftange, Dana Wegierak, Utku Goreke, Eric C Abenojar, Umut A Gurkan, Agata A Exner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Nanobubble Contrast Enhanced Ultrasound Imaging: A Review.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michaela B CooleyDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.ORCID 0000-0002-7955-3745
William J WulftangeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.ORCID 0000-0003-0708-3876
Dana WegierakDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.ORCID 0000-0003-1758-2417
Utku GorekeDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA. umut@case.edu.
Eric C AbenojarDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, USA. agata.exner@case.edu.ORCID 0000-0002-2733-4006
Umut A GurkanDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.ORCID 0000-0002-0331-9960
Agata A ExnerDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.ORCID 0000-0003-3913-7066

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Improved Detection of Prostate Cancer with Nanoparticle-based Ultrasound Contrast Agents Targeted to PSMAR01EB025741 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI James Peter Basilion, Agata A Exner · 2018 to 2026
$4.1M
Clinical and Translational Science Collaborative of ClevelandTL1TR000441 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$2.8M
Drug-Loaded Nanobubbles for Ultrasound Enhanced Delivery to Colon Cancer Liver MetastasisR01EB028144 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI EXNER, AGATA A · 2019 to 2023
$2.3M
Standardized Monitoring of Cellular Adhesion to Improve Clinical Care in Sickle Cell DiseaseR01HL133574 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI GURKAN, UMUT A., LITTLE, JANE · 2016 to 2020
$2.0M
Endothelialized microfluidic assays for emerging therapies in sickle cell diseaseR42HL160384 · NHLBI · BIOCHIP LABS, INC. · PI FEDERICI, CHIARA, GURKAN, UMUT A. · 2021 to 2023
$2.0M
CWRU- Cardiovascular Research Training ProgramT32HL134622 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR, PROWELLER, AARON · 2017 to 2021
$1.9M
Microfluidic intact cell platform: A novel tool for oral cancer detectionR21CA253108 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURKAN, UMUT A., WEINBERG, AARON · 2020 to 2020
$414k
Assessing vascular permeability and nanobubble extravasation with contrast-enhanced ultrasound imagingF30HL160111 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI COOLEY, MICHAELA · 2021 to 2023
$103k
NCATS NIH HHS TL1 TR000441NCI NIH HHS R21 CA253108NHLBI NIH HHS F30 HL160111NHLBI NIH HHS R01 HL133574NHLBI NIH HHS R42 HL160384NHLBI NIH HHS T32 HL134622NIBIB NIH HHS R01 EB025741NIBIB NIH HHS R01 EB028144NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Lipid shell-stabilized nanoparticles with a perfluorocarbon gas-core, or nanobubbles, have recently attracted attention as a new contrast agent for molecular ultrasound imaging and image-guided therapy. Due to their small size (∼275 nm diameter) and flexible shell, nanobubbles have been shown to extravasate through hyperpermeable vasculature (

Indexed as

Contrast MediaNeoplasmsExtracellular MatrixHumansMicrobubblesMicrofluidicsUltrasonographyContrast Media

Identifiers

PMID37424286
PMCPMC11684791

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.