Observational studyInfection control and hospital epidemiology2023
Characteristics, costs, and outcomes associated with central-line-associated bloodstream infection and hospital-onset bacteremia and fungemia in US hospitals.
Observational study in Infection control and hospital epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Impact of educational interventions provided to patients with a central venous catheter and their informal caregivers: a systematic review.Antimicrobial resistance and infection control · 2025Pooled it
- Development and implementation of a quality improvement framework for the prevention hospital-onset bacteremia and fungemia.Infection control and hospital epidemiology · 2026Article
- Hospital-Onset Bloodstream Infections: Progressive Shift from Methicillin-ResistantJournal of clinical medicine · 2026Article
- The burden of non-CLABSI hospital-onset bloodstream ınfections in pediatric wards outside the ıntensive care units.European journal of pediatrics · 2026Article
- Knowledge, attitude, and practice of central line-associated bloodstream infection prevention among intensive care unit nurses in Hebei Province, China: a cross-sectional study.Frontiers in public health · 2026Article
- Increased cost of care and length of stay due to potentially preventable catheter-related infections in US inpatient data, 2022-2023.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Approximating the cost-benefit analysis to a badge system to track hand hygiene in the hospital setting.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- A single-center study on epidemiology, microbial distribution, and mortality predictors in catheter-related bloodstream infections.BMC infectious diseases · 2025Article
- Central venous catheter infections: building a causal model with expert domain knowledge to inform future clinical trials.Antimicrobial resistance and infection control · 2025Article
- Integrating Nonindividual Patient Features in Machine Learning Models of Hospital-Onset Bacteremia.JAMA network open · 2025Article
- Hospital-onset bacteraemia and fungaemia as a novel automated surveillance indicator: results from four European university hospitals, 2018 to 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Observational
- Digitalised measures for the prevention of central line-associated bloodstream infections: a scoping review.Antimicrobial resistance and infection control · 2025Article
- Automated surveillance of hospital-onset bacteremia and fungemia: feasibility and epidemiological results from a Dutch multicenter study.Infection control and hospital epidemiology · 2025Article
- A Cross-Sectional Study of Catheter-Related Bloodstream Infections in a Tertiary Care Hospital in India.Cureus · 2025Article
- Universal vs Targeted Chlorhexidine Bathing and Nasal Decolonization in Hospitalized Patients.JAMA network open · 2025Article
- Prevention of Catheter-Related Infections and Complications: A Narrative Literature Review of Vascular Care and Maintenance.International journal of vascular medicine · 2025Review
- Treatment of positive catheter tip culture without bloodstream infections in critically ill patients. A case-cohort study from the OUTCOMEREA network.Intensive care medicine · 2024Article
- Catheter-associated urinary tract infections (CAUTIs) and non-CAUTI hospital-onset urinary tract infections: Relative burden, cost, outcomes and related hospital-onset bacteremia and fungemia infections.Infection control and hospital epidemiology · 2024Observational
- Beyond the surface: a color-inclusive guide to central line site assessment.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Trends and outcomes in community-onset and hospital-onsetAntimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare characteristics and outcomes associated with central-line-associated bloodstream infections (CLABSIs) and electronic health record-determined hospital-onset bacteremia and fungemia (HOB) cases in hospitalized US adults.
methodsWe conducted a retrospective observational study of patients in 41 acute-care hospitals. CLABSI cases were defined as those reported to the National Healthcare Safety Network (NHSN). HOB was defined as a positive blood culture with an eligible bloodstream organism collected during the hospital-onset period (ie, on or after day 4). We evaluated patient characteristics, other positive cultures (urine, respiratory, or skin and soft-tissue), and microorganisms in a cross-sectional analysis cohort. We explored adjusted patient outcomes [length of stay (LOS), hospital cost, and mortality] in a 1:5 case-matched cohort.
resultsThe cross-sectional analysis included 403 patients with NHSN-reportable CLABSIs and 1,574 with non-CLABSI HOB. A positive non-bloodstream culture with the same microorganism as in the bloodstream was reported in 9.2% of CLABSI patients and 32.0% of non-CLABSI HOB patients, most commonly urine or respiratory cultures. Coagulase-negative staphylococci and Enterobacteriaceae were the most common microorganisms in CLABSI and non-CLABSI HOB cases, respectively. In case-matched analyses, CLABSIs and non-CLABSI HOB, separately or combined, were associated with significantly longer LOS [difference, 12.1-17.4 days depending on intensive care unit (ICU) status], higher costs (by $25,207-$55,001 per admission), and a >3.5-fold increased risk of mortality in patients with an ICU encounter.
conclusionsCLABSI and non-CLABSI HOB cases are associated with significant increases in morbidity, mortality, and cost. Our data may help inform prevention and management of bloodstream infections.
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