ArticleBMC medicine2023
Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia.
Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Inflammation as a mediating pathway between social defeat and mental health in humans: A systematic review.Translational psychiatry · 2026Pooled it
- Neuroanatomical and transcriptomic correlates of attention in schizophrenia.Schizophrenia research. Cognition · 2026Article
- Sunshine duration and episodes of mental disorders and the inverse effect modification by ambient temperature.BMC medicine · 2026Article
- Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Recent developments in imaging transcriptomics for psychiatric disorders.Psychoradiology · 2026Review
- Causal association between plasma inflammatory proteins and longitudinal brain atrophy: a bidirectional Mendelian randomisation study.Brain imaging and behavior · 2025Article
- From shared mechanisms to treatment gaps: a review of the comorbidity between eating disorders and PTSD.Journal of eating disorders · 2025Review
- Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions.International journal of molecular sciences · 2025Article
- Cognitive implications and associated transcriptomic signatures of distinct regional iron depositions in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Brain imaging data and summary data-based Mendelian randomization analysis reveal the impact of multiorgan aging on schizophrenia.Frontiers in psychiatry · 2025Article
- The relationship between cognitive function and cortical thickness in first-episode drug-naive schizophrenia patients with agitation.Frontiers in psychiatry · 2025Article
- Review
- Impact of second-generation antipsychotics monotherapy or combined therapy in cytokine, lymphocyte subtype, and thyroid antibodies for schizophrenia: a retrospective study.BMC psychiatry · 2024Article
- Ambient Air Pollution and Hospitalizations for Schizophrenia in China.JAMA network open · 2024Article
- Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia.BMC psychiatry · 2024Article
- Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neuroimaging of neuropsychological disturbances following ischaemic stroke (CONNECT): a prospective cohort study protocol.BMJ open · 2024Article
- Combined Predictors for the Diagnostic Transition from Acute and Transient Psychotic Disorder to Schizophrenia: A Retrospective Study.Neuropsychiatric disease and treatment · 2024Article
- Hematological and inflammatory markers in Han Chinese patients with drug-free schizophrenia: relationship with symptom severity.Frontiers in immunology · 2024Article
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Authors and funding
14 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation has been implicated in the pathology of schizophrenia and may cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted longitudinal brain structural changes in patients with schizophrenia, yet it is unclear whether this is related to inflammation. We aim to address this question, by relating brain structural changes with the transcriptional profile of inflammation markers in the early stage of schizophrenia.
methodsThirty-eight patients with first-episode schizophrenia and 51 healthy controls were included. High-resolution T1-weighted magnetic resonance imaging (MRI) and clinical assessments were performed at baseline and 2 ~ 6 months follow-up for all subjects. Changes in the brain structure were analyzed using surface-based morphological analysis and correlated with the expression of immune cells-related gene sets of interest reported by previous reviews. Transcriptional data were retrieved from the Allen Human Brain Atlas. Furthermore, we examined the brain structural changes and peripheral inflammation markers in association with behavioral symptoms and cognitive functioning in patients.
resultsPatients exhibited accelerated cortical thickness decrease in the left frontal cortices, less decrease or an increase in the superior parietal lobule and right lateral occipital lobe, and increased volume in the bilateral pallidum, compared with controls. Changes in cortical thickness correlated with the transcriptional level of monocyte across cortical regions in patients (r = 0.54, p < 0.01), but not in controls (r = - 0.05, p = 0.76). In addition, cortical thickness change in the left superior parietal lobule positively correlated with changes in digital span-backward test scores in patients.
conclusionsPatients with schizophrenia exhibit regional-specific cortical thickness changes in the prefrontal and parietooccipital cortices, which is related to their cognitive impairment. Inflammation may be an important factor contributing to cortical thinning in first-episode schizophrenia. Our findings suggest that the immunity-brain-behavior association may play a crucial role in the pathogenesis of schizophrenia.
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