Evidence map›Paper›PMID 37424010›Full record

ArticleThyroid research2023

Determinants and mediating mechanisms of quality of life and disease-specific symptoms among thyroid cancer patients: the design of the WaTCh study.

Floortje Mols, Dounya Schoormans, Romana Netea-Maier, Olga Husson, Sandra Beijer, Katrijn Van Deun, Wouter Zandee, Marleen Kars, Pleun C M Wouters van Poppel, Suat Simsek and 9 more

Abstract read
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In one paragraph

Article in Thyroid research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Adding home-use BIA scales, online food diaries, and tape-measures to large-scale questionnaire studies: Insights from the population-based PROFILES registry research.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  5. Remote blood collection among cancer patients and age- and sex-matched controls for biomarker and genetic analyses using the PROFILES registry.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Floortje MolsCoRPS - Center of Research On Psychological Disorders and Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands. F.Mols@tilburguniversity.edu.
Dounya SchoormansCoRPS - Center of Research On Psychological Disorders and Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.
Romana Netea-MaierDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Olga HussonDepartment of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Sandra BeijerNetherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands.
Katrijn Van DeunDepartment of Methodology and Statistics, Tilburg University, Tilburg, The Netherlands.
Wouter ZandeeDepartment of Endocrinology, Groningen University, University Medical Center Groningen, Groningen, The Netherlands.
Marleen KarsMaastricht University Medical Center (MUMC), Maastricht, the Netherlands.
Pleun C M Wouters van PoppelMaxima Medical Center, Veldhoven, The Netherlands.
Suat SimsekNoordwest Ziekenhuisgroep, Alkmaar, The Netherlands.
Patrick van BattumZuyderland MC Hospital, Heerlen, The Netherlands.
Jérôme M H KistersCatharina Hospital, Eindhoven, The Netherlands.
Jan Paul de BoerAntoni Van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Elske MassoltAlbert Schweitzer Hospital, Dordrecht, The Netherlands.
Rachel van LeeuwaardeDepartment of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Wilma OranjeETZ, Tilburg, The Netherlands.
Sean Roerink, Rijnstate, Arnhem, The Netherlands.
Mechteld VermeulenCWZ, Nijmegen, The Netherlands.
Lonneke van de Poll-FranseCoRPS - Center of Research On Psychological Disorders and Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThyroid cancer (TC) patients are understudied but appear to be at risk for poor physical and psychosocial outcomes. Knowledge of the course and determinants of these deteriorated outcomes is lacking. Furthermore, little is known about mediating biological mechanisms.

objectivesThe WaTCh-study aims to; 1. Examine the course of physical and psychosocial outcomes. 2. Examine the association of demographic, environmental, clinical, physiological, and personality characteristics to those outcomes. In other words, who is at risk? 3. Reveal the association of mediating biological mechanisms (inflammation, kynurenine pathway) with poor physical and psychological outcomes. In other words, why is a person at risk? DESIGN AND

methodsNewly diagnosed TC patients from 13 Dutch hospitals will be invited. Data collection will take place before treatment, and at 6, 12 and 24 months after diagnosis. Sociodemographic and clinical information is available from the Netherlands Cancer Registry. Patients fill-out validated questionnaires at each time-point to assess quality of life, TC-specific symptoms, physical activity, anxiety, depression, health care use, and employment. Patients are asked to donate blood three times to assess inflammation and kynurenine pathway. Optionally, at each occasion, patients can use a weighing scale with bioelectrical impedance analysis (BIA) system to assess body composition; can register food intake using an online food diary; and can wear an activity tracker to assess physical activity and sleep duration/quality. Representative Dutch normative data on the studied physical and psychosocial outcomes is already available. IMPACT: WaTCh will reveal the course of physical and psychosocial outcomes among TC patients over time and answers the question who is at risk for poor outcomes, and why. This knowledge can be used to provide personalized information, to improve screening, to develop and provide tailored treatment strategies and supportive care, to optimize outcomes, and ultimately increase the number of TC survivors that live in good health.

Indexed as

Activity trackersBIA weighing scalesFood diariesInflammationKynurenine pathwayPatient reported outcomesPROFILES registryThyroid cancer

Identifiers

PMID37424010
PMCPMC10332086

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.