ArticleScientific reports2023
Impact of text contrast polarity on the retinal activity in myopes and emmetropes using modified pattern ERG.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Sustained Plus Lens Defocus Alters Retinal Responses and Ciliary Muscle Morphology In Myopes and Near-emmetropes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Human accommodative visuomotor function is driven by contrast through ON and OFF pathways and is enhanced in myopia.Cell reports · 2026Article
- Multifocal electroretinography assessment of retinal responses to myopic defocus lenses.PeerJ · 2026Article
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake.Investigative ophthalmology & visual science · 2025Article
- Relative Role of ON/OFF Pathways in Resolving and Adapting to Blur in Myopes and Emmetropes.Investigative ophthalmology & visual science · 2025Article
- Optical influence of myopia control spectacles at the retinal level: Effect of local light modulation.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Retinal Responses to Short- and Longer-Term Predominant ON or OFF Stimulation in Emmetropes and Myopes.Investigative ophthalmology & visual science · 2025Article
- Contrast Sensitivity of ON and OFF Human Retinal Pathways in Myopia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Optical Strategy Utilizing Contrast Modulation to Slow Myopia.Ophthalmology scienceReview
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental factors favoring myopia development are still being studied and there is accumulating evidence for a significant role of nearwork. Recently, reading standard black-on-white text was found to activate the retinal OFF pathway and induce choroidal thinning, which is associated with myopia onset. Contrarily, reading white-on-black text led to thicker choroids, being protective against myopia. Respective effects on retinal processing are yet unknown. Here, we exploratively assessed the impact of contrast polarity on the retinal activity and possible interactions with eccentricity and refractive error. We recorded pattern electroretinograms in myopic and emmetropic adults while presenting a dead leaves stimulus (DLS), overlaid by masks of different size in ring or circle shape, either filled with uniform gray or text of inverted or standard contrast. In myopes, retinal responses for DLS with standard and inverted contrast were larger when the perifovea was stimulated (6-12 deg), however, including the fovea resulted in smaller amplitudes for inverted contrast than in emmetropes. The retina of emmetropes was more sensitive to inverted contrast than to standard and gray within 12 deg, but most sensitive for gray in the perifovea. This demonstrates that the refractive error influences the sensitivity to text contrast polarity, with a special role of the peripheral retina, which is in line with previous studies about blur sensitivity. Defining whether the differences derive from retinal processing or anatomical features of a myopic eye requires further investigation. Our approach might be a first step to explain how nearwork promotes the eye's elongation.
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