Evidence map›Paper›PMID 37423870›Full record

ReviewTrends in genetics : TIG2023

Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.

Xin Zhang, Patrick Leavey, Haley Appel, Neoklis Makrides, Seth Blackshaw

Open access · greenAbstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

  1. Convergent re-evolution of CNS structures: focus on the fovea.Current opinion in genetics & development · 2026
    Review
  2. Article
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  13. Timing neural development and regeneration.Current opinion in neurobiology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. New pathways to neurogenesis: Insights from injury-induced retinal regeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xin ZhangDepartment of Ophthalmology, Columbia University School of Medicine, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University School of Medicine, New York, NY, USA. Electronic address: xz2369@columbia.edu.
Patrick LeaveySolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Haley AppelSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neoklis MakridesDepartment of Ophthalmology, Columbia University School of Medicine, New York, NY, USA.
Seth BlackshawSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: sblack@jhmi.edu.
Johns Hopkins University · USColumbia University · US

Funding

Signaling Mechanisms of Lens DevelopmentR01EY017061 · NEI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ZHANG, XIN · 2006 to 2025
$9.0M
PDGF signaling in lens developmentR01EY025933 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHANG, XIN · 2015 to 2023
$3.2M
Identification of gene regulatory networks that control proliferative and neurogenic competence in mammalian Müller gliaR01EY031685 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2020 to 2023
$2.0M
NEI NIH HHS R01 EY017061NEI NIH HHS R01 EY025933NEI NIH HHS R01 EY031685
6 · The paper itself

Abstract

This review covers recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on insights obtained from comparative single cell multiomic analysis. We discuss recent advances in understanding the mechanisms by which extrinsic factors trigger transcriptional changes that spatially pattern the optic cup (OC) and control the initiation and progression of retinal neurogenesis. We also discuss progress in unraveling the core evolutionarily conserved gene regulatory networks (GRNs) that specify early- and late-state retinal progenitor cells (RPCs) and neurogenic progenitors and that control the final steps in determining cell identity. Finally, we discuss findings that provide insight into regulation of species-specific aspects of retinal patterning and neurogenesis, including consideration of key outstanding questions in the field.

Indexed as

NeurogenesisRetinaAnimalsCell DifferentiationGene Expression Regulation, DevelopmentalStem CellsVertebrates

Identifiers

PMID37423870
PMCPMC10529299
OpenAlexW4383620362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.