ArticleInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society2023
Characterization of pre-operative anemia in patients undergoing surgery by a gynecologic oncologist and association with post-operative complications.
Article in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Accuracy of minimally invasive hemoglobin monitoring in the perioperative period: transcutaneous hemoglobin monitoring and point-of-care testing devices: prospective observational study.Journal of clinical monitoring and computing · 2026Article
- Analysis of the incidence and risk factors of blood transfusion in robot-assisted laparoscopic total hysterectomy: a retrospective nationwide inpatient sample database study.Perioperative medicine (London, England) · 2025Article
- Anemia, Abnormal Body Mass Index, and Sarcopenia Increase Complication Risk in Patients Undergoing Surgical Treatment for Metastatic Bone Disease.Journal of surgical oncology · 2025Article
- Preoperative Anemia and Perioperative Outcomes in Gynecological Surgery: A Single-Center Retrospective Study.International journal of women's health · 2025Article
- Article
- Safe to save blood in ovarian cancer surgery - time to change transfusion habits.Acta oncologica (Stockholm, Sweden) · 2024Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAnemia is prevalent in patients with gynecologic cancers and is associated with increased peri-operative morbidity. We aimed to characterize risk factors for pre-operative anemia and describe outcomes among patients undergoing surgery by a gynecologic oncologist to identify potential areas for impactful intervention.
methodsWe analyzed major surgical cases performed by a gynecologic oncologist in the National Surgical Quality Improvement Program (NSQIP) database from 2014 to 2019. Anemia was defined as hematocrit <36%. Demographic characteristics and peri-operative variables for patients with and without anemia were compared using bivariable tests. Odds of peri-operative complications in patients stratified by pre-operative anemia were calculated using logistic regression models.
resultsAmong 60 017 patients undergoing surgery by a gynecologic oncologist, 23.1% had pre-operative anemia. Women with ovarian cancer had the highest rate of pre-operative anemia at 39.7%. Patients with advanced-stage cancer had a higher risk of anemia than early-stage disease (42.0% vs 16.3%, p≤0.001). In a logistic regression model adjusting for potential demographic, cancer-related, and surgical confounders, patients with pre-operative anemia had increased odds of infectious complications (odds ratio (OR) 1.16, 95% CI 1.07 to 1.26), thromboembolic complications (OR 1.39, 95% CI 1.15 to 1.68), and blood transfusion (OR 5.78, 95% CI 5.34 to 6.26).
conclusionsThere is a high rate of anemia in patients undergoing surgery by a gynecologic oncologist, particularly those with ovarian cancer and/or advanced malignancy. Pre-operative anemia is associated with increased odds of peri-operative complications. Interventions designed to screen for and treat anemia in this population have the potential for significant impact on surgical outcomes.
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