Evidence map›Paper›PMID 37423270›Full record

ArticleAnnals of epidemiology2023

Deprivation and segregation in ovarian cancer survival among African American women: a mediation analysis.

Andrew B Lawson, Joanne Kim, Courtney Johnson, Theresa Hastert, Elisa V Bandera, Anthony J Alberg, Paul Terry, Maxwell Akonde, Hannah Mandle, Michele L Cote and 7 more

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In one paragraph

Article in Annals of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Socioeconomic disadvantage and the risk for adverse post-operative outcomes after gynecologic cancer surgery.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2025
    Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andrew B LawsonDepartment of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; Usher Institute, Centre for Population Health Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK. Electronic address: lawsonab@musc.edu.
Joanne KimDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus.
Courtney JohnsonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Theresa HastertDepartment of Oncology, Wayne State University School of Medicine, Population Studies and Disparities Research Program, Karmanos Cancer Institute, Detroit, MI.
Elisa V BanderaCancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick.
Anthony J AlbergDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia.
Paul TerryDepartment of Medicine, University of Tennessee Medical Center-Knoxville, Knoxville.
Maxwell AkondeDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia.
Hannah MandleDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Michele L CoteIndiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis.
Melissa BondyDepartment of Epidemiology and Population Health, Stanford University, College of Medicine, Stanford, CA.
Jeffrey MarksDepartment of Surgery, Duke University School of Medicine, Durham, NC.
Lauren PeresDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Kendra L RatnapradipaDepartment of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha.
Yao XinDepartment of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston.
Joellen SchildkrautDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Edward S PetersDepartment of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha.

Funding

Ovarian Cancer Survival in African-American WomenR01CA237318 · NCI · EMORY UNIVERSITY · PI LAWSON, ANDREW B., SCHILDKRAUT, JOELLEN M. · 2020 to 2024
$5.9M
NCI NIH HHS R01 CA237318
6 · The paper itself

Abstract

purposeDeprivation and segregation indices are often examined as possible explanations for observed health disparities in population-based studies. In this study, we assessed the role of recognized deprivation and segregation indices specifically as they affect survival in a cohort of self-identified Black women diagnosed with ovarian cancer who enrolled in the African American Cancer Epidemiology Study.

methodsMediation analysis was used to examine the direct and indirect effects between deprivation or segregation and overall survival via a Bayesian structural equation model with Gibbs variable selection.

resultsThe results suggest that high socioeconomic status-related indices have an association with increased survival, ranging from 25% to 56%. In contrast, index of concentration at the extremes-race does not have a significant impact on overall survival. In many cases, the indirect effects have very wide credible intervals; consequently, the total effect is not well estimated despite the estimation of the direct effect.

conclusionsOur results show that Black women living in higher socioeconomic status neighborhoods are associated with increased survival with ovarian cancer using area-level economic indices such as Yost or index of concentration at the extremes-income. In addition, the Kolak urbanization index has a similar impact and highlights the importance of area-level deprivation and segregation as potentially modifiable social factors in ovarian cancer survival.

Indexed as

Health Status DisparitiesMediation AnalysisOvarian NeoplasmsBayes TheoremBlack or African AmericanFemaleHumansIncomeSocial DeprivationSocial Determinants of HealthSocial SegregationSurvival RateAACES 1 cohortBayesianCausal mediationDeprivation indicesDiagnostic delayICEOvarian cancerStructural equationSurvivalYost

Identifiers

PMID37423270
PMCPMC10538403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.