Evidence map›Paper›PMID 37422949›Full record

ArticleStem cell research2023

Generation of a human Tropomyosin 1 knockout iPSC line.

Madison B Wilken, Jean Ann Maguire, Lea V Dungan, Alyssa Gagne, Catherine Osorio-Quintero, Elisa A Waxman, Stella T Chou, Paul Gadue, Deborah L French, Christopher S Thom

Abstract read
In one paragraph

Article in Stem cell research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Madison B WilkenDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jean Ann MaguireCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lea V DunganCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alyssa GagneCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Catherine Osorio-QuinteroCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Elisa A WaxmanCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Stella T ChouDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Paul GadueCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Deborah L FrenchCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Christopher S ThomDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: thomc@chop.edu.

Funding

Improving transfusion therapy for patients with sickle cell disease with pluripotent stem cell-derived red cellsU01HL134696 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI CHOU, STELLA T · 2016 to 2022
$8.3M
Determining genetic mechanisms that drive in vitro hematopoiesisK99HL156052 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI THOM, CHRISTOPHER STEPHEN · 2021 to 2024
$670k
NHLBI NIH HHS K99 HL156052NHLBI NIH HHS U01 HL134696
6 · The paper itself

Abstract

The CHOPWT17_TPM1KOc28 iPSC line was generated to interrogate the functions of Tropomyosin 1 (TPM1) in primary human cell development. This line was reprogrammed from a previously published wild type control iPSC line.

Indexed as

Induced Pluripotent Stem CellsTropomyosinCell Line, TumorHumansTropomyosin

Identifiers

PMID37422949
PMCPMC10507314

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.