Evidence map›Paper›PMID 37422842›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2023

Prevalence of Diabetic Kidney Disease with Different Subtypes in Hospitalized Patients with Diabetes and Correlation Between eGFR and LncRNA XIST Expression in PBMCs.

Yingbei Lin, Peili Wu, Lei Guo, Qijian Feng, Ling Wang, Xiaochun Lin, Chuyi Yang, Nannan Liu, Churan Wen, Xuelin Li and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yingbei Lin *Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Peili Wu *Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Lei Guo *Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Qijian FengDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Ling WangDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Xiaochun LinDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Chuyi YangDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Nannan LiuDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Churan WenDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Xuelin LiDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Xiaoqin MaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Yaoming XueDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China.
Meiping GuanDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangdong, China. mpguan@smu.edu.cn.
Nanfang Hospital · CNSouthern Medical University · CN

Funding

National Natural Science Foundation of China 81870612National Natural Science Foundation of China 82270858
6 · The paper itself

Abstract

introductionDiabetic kidney disease (DKD) has become the leading cause of end-stage kidney disease (ESKD) in most countries. Recently, long noncoding RNA XIST has been found involved in the development of DKD.

methodsA total of 1184 hospitalized patients with diabetes were included and divided into four groups based on their estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (UACR): normal control group (nDKD), DKD with normoalbuminuric and reduced eGFR (NA-DKD), DKD with albuminuria but without reduced eGFR (A-DKD), and DKD with albuminuria and reduced eGFR (Mixed), and then their clinical characteristics were analyzed. Peripheral blood mononuclear cells (PBMCs) of patients with DKD were isolated, and lncRNA XIST expression was detected by real-time quantitative PCR.

resultsThe prevalence of DKD in hospitalized patients with diabetes mellutus (DM) was 39.9%, and the prevalence of albuminuria and decreased eGFR was 36.6% and 16.2%, respectively. NA-DKD, A-DKD, and Mixed groups accounted for 23.7%, 3.3%, and 12.9%, respectively. Women with DKD had considerably lower levels of lncRNA XIST expression in their PBMCs compared to nDKD. There was a significant correlation between eGFR level and lncRNA XIST expression (R = 0.390, P = 0.036) as well as a negative correlation between HbA1c and lncRNA XIST expression (R = - 0.425, P = 0.027) in female patients with DKD.

conclusionsOur study revealed that 39.9% of DM inpatients who were admitted to the hospital had DKD. Importantly, lncRNA XIST expression in PBMCs of female patients with DKD was significantly correlated with eGFR and HbA1c.

Indexed as

Diabetic kidney diseaseLong non-coding RNANormoalbuminuric diabetic kidney diseaseXist

Identifiers

PMID37422842
PMCPMC10363095
OpenAlexW4383668076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.